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Nanotechnology and single cell proteomics as a diagnostic tool

Heath, James R. and Wei, Wei and Shin, Young Shik and Xue, Min and Zhou, Jing and Sutherland, Alex and Yu, Jing (2014) Nanotechnology and single cell proteomics as a diagnostic tool. Cancer Research, 74 (19 Suppleme). Art. No. SY23-02. ISSN 0008-5472. http://resolver.caltech.edu/CaltechAUTHORS:20150604-142522878

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Abstract

Single-cell functional proteomics assays can connect genomic information to biological function through the use of quantitative and multiplex protein measurements. Tools for single-cell proteomics have developed rapidly over the past 5 years, and are providing approaches for directly elucidating phospho-protein signaling networks in cancer cells, or for capturing high-resolution snapshots of immune system function in cancer patients participating therapies that involve immune system engineering and manipulation. We discuss advances in single cell proteomics platforms, with an emphasis the types of data that can be obtained, and how analysis of that data can provide deep insights into either designing therapies, or understanding patient responses to therapies. I will provide illustrative examples of how microchip-based single cell functional proteomics platforms are being applied to both fundamental biology and clinical studies.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1158/1538-7445.AM2014-SY23-02DOIArticle
http://cancerres.aacrjournals.org/content/74/19_Supplement/SY23-02PublisherArticle
ORCID:
AuthorORCID
Heath, James R.0000-0001-5356-4385
Additional Information:©2014 American Association for Cancer Research.
Record Number:CaltechAUTHORS:20150604-142522878
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20150604-142522878
Official Citation:James R. Heath, Wei Wei, Young Shik Shin, Min Xue, Jing Zhou, Alex Sutherland, Jing Yu. Nanotechnology and single cell proteomics as a diagnostic tool. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr SY23-02. doi:10.1158/1538-7445.AM2014-SY23-02
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:58014
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:04 Jun 2015 21:44
Last Modified:04 Jun 2015 21:44

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