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Simulation and measurement of transcranial near infrared light penetration

Yue, Lan and Monge, Manuel and Ozgur, Mehmet H. and Murphy, Kevin and Louie, Stan and Miller, Carol A. and Emami, Azita and Humayun, Mark S. (2015) Simulation and measurement of transcranial near infrared light penetration. In: Optical Interactions with Tissue and Cells XXVI. Proceedings of SPIE. No.9321. SPIE , Bellingham, Washington, Art. No. 93210S. ISBN 978-1-62841-411-0. https://resolver.caltech.edu/CaltechAUTHORS:20150605-135556686

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Abstract

We are studying the transmission of LED array-emitted near-infrared (NIR) light through human tissues. Herein, we simulated and measured transcranial NIR penetration in highly scattering human head tissues. Using finite element analysis, we simulated photon diffusion in a multilayered 3D human head model that consists of scalp, skull, cerebral spinal fluid, gray matter and white matter. The optical properties of each layer, namely scattering and absorption coefficient, correspond to the 850 nm NIR light. The geometry of the model is minimally modified from the IEEE standard and the multiple LED emitters in an array were evenly distributed on the scalp. Our results show that photon distribution produced by the array exhibits little variation at similar brain depth, suggesting that due to strong scattering effects of the tissues, discrete spatial arrangements of LED emitters in an array has the potential to create a quasi-radially symmetrical illumination field. Measurements on cadaveric human head tissues excised from occipital, parietal, frontal and temporal regions show that illumination with an 850 nm LED emitter rendered a photon flux that closely follows simulation results. In addition, prolonged illumination of LED emitted NIR showed minimal thermal effects on the brain.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1117/12.2077019DOIArticle
http://proceedings.spiedigitallibrary.org/proceeding.aspx?articleid=2196092PublisherArticle
ORCID:
AuthorORCID
Monge, Manuel0000-0001-9799-0693
Emami, Azita0000-0003-2608-9691
Humayun, Mark S.0000-0002-5830-5208
Additional Information:© 2015 SPIE.
Subject Keywords:near-infrared light; transcranial penetration; LED array; finite element analysis
Series Name:Proceedings of SPIE
Issue or Number:9321
Record Number:CaltechAUTHORS:20150605-135556686
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150605-135556686
Official Citation:Lan Yue ; Manuel Monge ; Mehmet H. Ozgur ; Kevin Murphy ; Stan Louie, et al. "Simulation and measurement of transcranial near infrared light penetration ", Proc. SPIE 9321, Optical Interactions with Tissue and Cells XXVI, 93210S (March 5, 2015); doi:10.1117/12.2077019; http://dx.doi.org/10.1117/12.2077019
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:58056
Collection:CaltechAUTHORS
Deposited By: Jason Perez
Deposited On:09 Jun 2015 18:31
Last Modified:09 Mar 2020 13:18

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