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Rapid and opposite effects of BDNF and NGF on the functional organization of the adult cortex in vivo

Prakash, Neal and Cohen-Cory, Susana and Frostig, Ron D. (1996) Rapid and opposite effects of BDNF and NGF on the functional organization of the adult cortex in vivo. Nature, 381 (6584). pp. 702-706. ISSN 0028-0836. http://resolver.caltech.edu/CaltechAUTHORS:20150610-152828499

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Abstract

THE adult cortex is thought to undergo plastic changes that are closely dependent on neuronal activity (reviewed in ref. 1), although it is not yet known what molecules are involved. Neurotrophins and their receptors have been implicated in several aspects of developmental plasticity, and their expression in the adult cortex suggests additional roles in adult plasticity. To examine these potential roles in vivo, we used intrinsic-signal optical imaging to quantify the effects of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) on the functional representation of a stimulated whisker in the 'barrel' subdivision of the rat somatosensory cortex. Topical application of BDNF resulted in a rapid and long-lasting decrease in the size of a whisker representation, and a decrease in the amplitude of the activity-dependent intrinsic signal. In contrast, NGF application resulted in a rapid but transient increase in the size of a representation, and an increase in the amplitude of the activity-dependent intrinsic signal. These results demonstrate that neurotrophins can rapidly modulate stimulus-dependent activity in adult cortex, and suggest a role for neurotrophins in regulating adult cortical plasticity.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1038/381702a0DOIArticle
http://www.nature.com/nature/journal/v381/n6584/abs/381702a0.htmlPublisherArticle
Additional Information:© 1996 Nature Publishing Group. Received 3 January; accepted 28 April 1996. We thank Amgen Inc. for BDNF; Genentech Inc. for NGF; J. Carnahan for BDNF antibodies; 0. 0. Clary for TrkA antibodies; D. Kaplan for TrkB antibodies; and S. E. Fraser for support and comments on the manuscript. This work was supported in part by NIMH, NSF, the UCI Markey Program in Human Neurobiology (R.D.F.). the UCI Medical Scientist Training Program (N.P.), and the Helen Hay Whitney Foundation and NIMH (S.C.-C.).
Funders:
Funding AgencyGrant Number
NIMHUNSPECIFIED
NSFUNSPECIFIED
University of California, Irvine Markey Program in Human NeurobiologyUNSPECIFIED
University of California, Irvine Medical Scientist Training ProgramUNSPECIFIED
Helen Hay Whitney FoundationUNSPECIFIED
Record Number:CaltechAUTHORS:20150610-152828499
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20150610-152828499
Official Citation:Rapid and opposite effects of BDNF and NGF on the functional organization of the adult cortex in vivo 702-706 Neal Prakash, Susana Cohen-Cory & Ron D. Frostig doi:10.1038/381702a0
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:58174
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:11 Jun 2015 15:50
Last Modified:11 Jun 2015 15:50

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