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Crystal structure of the complex of rat neonatal Fc receptor with Fc

Burmeister, Wilhelm P. and Huber, Andrew H. and Bjorkman, Pamela J. (1994) Crystal structure of the complex of rat neonatal Fc receptor with Fc. Nature, 372 (6504). pp. 379-383. ISSN 0028-0836. https://resolver.caltech.edu/CaltechAUTHORS:20150611-121726675

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Abstract

The neonatal Fc receptor (FcRn) transports maternal immunoglobulin G (IgG) to the bloodstream of the newborn. FcRn is structurally similar to class I major histocompatibility complex (MHC) molecules, despite differences in the ligands they bind (the Fc portion of IgG and antigenic peptides, respectively). A low-resolution crystal structure of the complex between FcRn and Fc localizes the binding site for Fc to the side of FcRn, distinct from the tops of the αl and α2 domains which serve as the peptide and T-cell receptor binding sites in class I molecules. FcRn binds to Fc at the interface between the Fc C_H2 and C_H3 domains, which contains several histidine residues that could account for the sharply pH-dependent FcRn/IgG interaction. A dimer of FcRn heterodimers observed in the co-crystals and in the crystals of FcRn alone could be involved in binding Fc, correlating with the 2:1 binding stoichiometry between FcRn and IgG (ref. 4) and suggesting an unusual orientation of FcRn on the membrane.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1038/372379a0DOIArticle
http://www.nature.com/nature/journal/v372/n6504/abs/372379a0.htmlPublisherArticle
ORCID:
AuthorORCID
Bjorkman, Pamela J.0000-0002-2277-3990
Additional Information:© 1994 Nature Publishing Group. Received 29 June; Accepted 6 October 1994. We thank D. Sabatini for suggesting that networks of complexes could exist between adjacent microvilli; D. Vaughn for help with data collection; the staff at CHESS; and M. Raghavan, L Gastinel and N. Simister for critical reading of the manuscript. Coordinates will be deposited in the Brookhaven databank and can be requested by e-mail (burmeister@citray.caltech.edu). This work was supported by the Howard Hughes Medical Institute (P.J.B.) and an EMBO fellowship (W.P.B.). A.H.H. was supported by a Howard Hughes Predoctoral Fellowship.
Funders:
Funding AgencyGrant Number
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
European Molecular Biology Organization (EMBO)UNSPECIFIED
Issue or Number:6504
Record Number:CaltechAUTHORS:20150611-121726675
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150611-121726675
Official Citation:Burmeister, W. P., Huber, A. H., & Bjorkman, P. J. (1994). Crystal structure of the complex of rat neonatal Fc receptor with Fc. [10.1038/372379a0]. Nature, 372(6504), 379-383.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:58198
Collection:CaltechAUTHORS
Deposited By: Joanne McCole
Deposited On:12 Jun 2015 19:28
Last Modified:03 Oct 2019 08:33

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