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G Protein-Coupled Odorant Receptors: from sequence to structure

de March, Claire and Kim, Soo-Kyung and Antonczak, Serge and Goddard, William A., III and Golebiowski, Jérôme (2015) G Protein-Coupled Odorant Receptors: from sequence to structure. Protein Science, 24 (9). pp. 1543-1548. ISSN 0961-8368. PMCID PMC4570547. https://resolver.caltech.edu/CaltechAUTHORS:20150615-153012612

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Abstract

Odorant receptors (ORs) are the largest sub-family within Class-A G Protein-Coupled Receptors (GPCRs). No experimental structural data of any OR is available to date and atomic-level insights are likely to be obtained by means of molecular modeling. In this article, we critically align sequences of ORs with those GPCRs for which a structure is available. Here, an alignment consistent with available site-directed mutagenesis data on various ORs is proposed. Using this alignment, the choice of the template is deemed rather minor for identifying residues that constitute the wall of the binding cavity or those involved in G-protein recognition.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1002/pro.2717DOIArticle
http://onlinelibrary.wiley.com/doi/10.1002/pro.2717/abstractPublisherArticle
http://onlinelibrary.wiley.com/doi/10.1002/pro.2717/suppinfoPublisherSupplemental Information
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4570547/PubMed CentralArticle
ORCID:
AuthorORCID
Kim, Soo-Kyung0000-0002-4498-5441
Goddard, William A., III0000-0003-0097-5716
Additional Information:© 2015 The Protein Society. Manuscript Accepted: 25 May 2015; Manuscript Received: 24 Mar 2015. Accepted manuscript online: 5 Jun 2015. This work was supported by grants from APEX Region PACA to J. G. (OLFACTOME) and from the Fondation Roudnitska under the aegis of Fondation de France to C.A.D.M.
Funders:
Funding AgencyGrant Number
APEX Region PACAUNSPECIFIED
Fondation RoudnitskaUNSPECIFIED
Fondation de FranceUNSPECIFIED
Subject Keywords:odorant receptor; sequence; structure; binding cavity; olfactory
Issue or Number:9
PubMed Central ID:PMC4570547
Record Number:CaltechAUTHORS:20150615-153012612
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150615-153012612
Official Citation:de March, C. A., Kim, S.-K., Antonczak, S., Goddard, W. A. and Golebiowski, J. (2015), G protein-coupled odorant receptors: From sequence to structure. Protein Science, 24: 1543–1548. doi: 10.1002/pro.2717
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:58264
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:16 Jun 2015 16:32
Last Modified:09 Mar 2020 13:18

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