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A glucose-sensing polymer

Chen, Guohua and Guan, Zhibin and Chen, Chao-Tsen and Fu, Litian and Sundaresan, Vidyasankar and Arnold, Frances H. (1997) A glucose-sensing polymer. Nature Biotechnology, 15 (4). pp. 354-357. ISSN 1087-0156. doi:10.1038/nbt0497-354.

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We have prepared a robust polymer that can be used to measure glucose concentrations in complex biological media. At alkaline pH, the metal-complexing polymer binds glucose and instantly releases protons in proportion to the glucose concentration over a clinically relevant range (0 to 25 mM). The inexpensive polymer is sufficiently selective to provide an easily measurable response to glucose in porcine plasma. The polymer's ability to function at nonphysiological pH (at which the buffer capacity of biological samples is small) makes it possible to design simple and inexpensive sensing devices based on measurement of changes in proton concentration.

Item Type:Article
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Arnold, Frances H.0000-0002-4027-364X
Additional Information:© 1997 Nature Publishing Group. Received 17 December 1996; accepted 11 February 1997. This research was supported in part by the US National Science Foundation. GC is supported by a postdoctoral fellowship from the NIGMS.
Funding AgencyGrant Number
NIH Postdoctoral FellowshipUNSPECIFIED
Subject Keywords:diabetes mellitus, biosensor, copper-thriazacyclononane, molecular imprinting
Issue or Number:4
Record Number:CaltechAUTHORS:20150618-141848730
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:58352
Deposited By: Ruth Sustaita
Deposited On:18 Jun 2015 21:44
Last Modified:10 Nov 2021 22:03

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