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A glucose-sensing polymer

Chen, G. and Guan, Z. and Chen, C.-T. and Fu, L. and Sundaresan, V. and Arnold, F. H. (1997) A glucose-sensing polymer. Abstracts of Papers of the American Chemical Society, 213 . 234-PMSE. ISSN 0065-7727 .

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We have prepared robust polymers that can be used to measure glucose concentrations in complex biological media. These materials offer the potential to develop continuous glucose monitoring systems as well as extremely inexpensive devices for 'spot' blood glucose level measurements. At alkaline pH, a porous imprinted polymer containing the metal complex triazacyclononane-copper(II) (TACN-Cu^(2+)) binds glucose and releases protons in proportion to the surrounding glucose concentration. The proton response is extremely rapid and provides a convenient measure of the glucose concentration over a clinically relevant range (0-25 mM). The inexpensive, robust metal-complexing polymer is sufficiently selective to provide an easily measurable response to glucose in porcine plasma. The polymer's ability to function at pH values as high as 12 (which deactivate enzymes but at which the buffer capacity of blood is small) makes it possible to design simple and inexpensive sensing devices based on measurement of changes in pH.

Item Type:Article
Arnold, F. H.0000-0002-4027-364X
Additional Information:© 1997 American Chemical Society.
Record Number:CaltechAUTHORS:20150623-100021833
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:58438
Deposited By: Tony Diaz
Deposited On:23 Jun 2015 17:56
Last Modified:13 Sep 2017 16:17

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