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Involvement of striate and extrastriate visual cortical areas in spatial attention

Martínez, A. and Anllo-Vento, L. and Sereno, M. I. (1999) Involvement of striate and extrastriate visual cortical areas in spatial attention. Nature Neuroscience, 2 (4). pp. 364-369. ISSN 1097-6256. doi:10.1038/7274.

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We investigated the cortical mechanisms of visual-spatial attention while subjects discriminated patterned targets within distractor arrays. Functional magnetic resonance imaging (fMRI) was used to map the boundaries of retinotopic visual areas and to localize attention-related changes in neural activity within several of those areas, including primary visual (striate) cortex. Event-related potentials (ERPs) and modeling of their neural sources, however, indicated that the initial sensory input to striate cortex at 50−55 milliseconds after the stimulus was not modulated by attention. The earliest facilitation of attended signals was observed in extrastriate visual areas, at 70−75 milliseconds. We hypothesize that the striate cortex modulation found with fMRI may represent a delayed, re-entrant feedback from higher visual areas or a sustained biasing of striate cortical neurons during attention. ERP recordings provide critical temporal information for analyzing the functional neuroanatomy of visual attention.

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Additional Information:© 1999 Nature Publishing Group. Received 18 October 1998; accepted 18 February 1999. We thank Matt Marlow, Cecelia Kemper and Carlos Nava for technical assistance. Supported by grants from NIMH (MH25594), ONR (N00014-93-0942), NIH (NS36722), HMRI, and from the Deutsch Forschungsgemeinschaft (HE 1531/3).
Funding AgencyGrant Number
Office of Naval Research (ONR)N00014-93-0942
Huntington Medical Research InstitutesUNSPECIFIED
Deutsche Forschungsgemeinschaft (DFG)HE 1531/3
Issue or Number:4
Record Number:CaltechAUTHORS:20150624-084328923
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Official Citation:Martinez, A., Anllo-Vento, L., Sereno, M. I., Frank, L. R., Buxton, R. B., Dubowitz, D. J., . . . Hillyard, S. A. (1999). Involvement of striate and extrastriate visual cortical areas in spatial attention. [10.1038/7274]. Nat Neurosci, 2(4), 364-369.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:58572
Deposited On:24 Jun 2015 20:38
Last Modified:10 Nov 2021 22:07

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