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Measurement of viscosity of unadulterated human whole blood using a capillary pressure-driven viscometer

Kang, Dongyang and Wang, Wei and Lee, Juhyun and Tai, Yu-Chong and Hsiai, Tzung K. (2015) Measurement of viscosity of unadulterated human whole blood using a capillary pressure-driven viscometer. In: IEEE 10th International Conference on Nano/Micro Engineered and Molecular Systems. IEEE , Piscataway, NJ, pp. 1-4. https://resolver.caltech.edu/CaltechAUTHORS:20150717-124510753

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Abstract

This paper presents the experimental work on the measurement of unadulterated human whole blood viscosity using a capillary-based microfluidic viscometer. The viscosity was measured by monitoring the time-varying length and mean advancing velocity of the blood column inside the viscometer. A high-aspect-ratio microfluidic channel is preferred for the device geometrical configuration. Theoretical modeling and numerical algorithms were applied to obtain the blood viscosity over a wide range of shear rates. Power law and Carreau-Yasuda models were used to model the non-Newtonian behavior of the human whole blood. The proposed approach is uniquely applicable for small sample volume (<2µL), and short measurement time (<2 min). A wide range of shear rates (varying from of 71.4s^(−1) to 5492.1s^(−1)) is produced in a single test.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1109/NEMS.2015.7147343 DOIArticle
ORCID:
AuthorORCID
Wang, Wei0000-0002-5257-7675
Tai, Yu-Chong0000-0001-8529-106X
Hsiai, Tzung K.0000-0003-1734-0792
Additional Information:© 2015 IEEE. The authors gratefully acknowledge the help from all the members of the Caltech Micromachining Lab and the UCLA Cardiovascular Engineering Research Laboratory.
Subject Keywords:unadulterated human whole blood viscosity; capillary pressure-driven viscometer; non-Newtonian fluid
Record Number:CaltechAUTHORS:20150717-124510753
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150717-124510753
Official Citation:Dongyang Kang; Wei Wang; Juhyun Lee; Tai, Yu-Chong; Hsiai, Tzung K., "Measurement of viscosity of unadulterated human whole blood using a capillary pressure-driven viscometer," Nano/Micro Engineered and Molecular Systems (NEMS), 2015 IEEE 10th International Conference on , vol., no., pp.1,4, 7-11 April 2015 doi: 10.1109/NEMS.2015.7147343 URL: http://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=7147343&isnumber=7147342
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:58923
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:21 Jul 2015 21:42
Last Modified:25 Nov 2019 23:40

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