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The role of microRNA in nutritional control

Nolte-'t Hoen, E. N. M. and Van Rooij, E. and Bushell, M. and Zhang, C.-Y. and Dashwood, R. H. and James, W. P. T. and Harris, C. and Baltimore, D. (2015) The role of microRNA in nutritional control. Journal of Internal Medicine, 278 (2). pp. 99-109. ISSN 0954-6820. https://resolver.caltech.edu/CaltechAUTHORS:20150720-140634045

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Abstract

MicroRNAs (miRNAs) are one of a growing class of noncoding RNAs that are involved in the regulation of a wide range of metabolic processes including cellular differentiation, cell proliferation and apoptosis. The generation of miRNA is regulated in complex ways, for example by small interfering RNAs (small nucleolar and nuclear RNAs) and various other metabolites. This complexity of control is likely to explain how a relatively small part of the DNA that codes for proteins has enabled the evolution of such complex organisms as mammals. Non-protein-coding DNA is therefore thought to carry the memory of early evolutionary steps that led to progressively complex metabolic controls. Clinically, miRNAs are becoming increasingly important following the recognition that some congenital abnormalities can be traced to defects in miRNA processing. The potential for manipulating metabolism and affecting disease processes by the pharmaceutical or biological targeting of specific miRNA pathways is now being tested. miRNAs are also released into the extracellular milieu after packaging by cells into nano-sized extracellular vesicles. Such vesicles can be taken up by adjacent and possibly more distant cells, thereby allowing coordinated intercellular communication in specific tissues. Extracellular miRNAs found in the blood stream may also serve as novel biomarkers for both diagnosing specific forms of cancer and assessing the likelihood of metastasis, and as powerful prognostic indices for various cancers. Here, we discuss the role of intracellular and extracellular miRNAs in nutritional control of various (patho)physiological processes. In this review, we provide an update of the presentations from the 25th Marabou Symposium (Stockholm, 14–16 June 2013) entitled ‘Role of miRNA in health and nutrition’, attended by 50 international experts.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1111/joim.12372DOIArticle
http://onlinelibrary.wiley.com/doi/10.1111/joim.12372/abstractPublisherArticle
ORCID:
AuthorORCID
Baltimore, D.0000-0001-8723-8190
Additional Information:© 2015 The Association for the Publication of the Journal of Internal Medicine. Conflict of interest statement: Drs Dashwood, Bushell, James, and Harris have nothing to disclose. Dr Nolte-’t Hoen reports a grant (11676) from a partnership programme jointly funded by Nutricia Research and the Dutch Technology Foundation STW, which is part of the Netherlands Organization for Scientific Research (NWO), and is partly funded by the Ministry of Economic Affairs, during the conduct of the study. Dr Zhang reports grants from Ministry of Science and Technology of the People’s Republic of China, grants from National Natural Science Foundation of China, during the conduct of the study. Dr van Rooij reports personal fees from miRagen Therapeutics, related to the subject matter and has several issued patents. Dr Baltimore reports personal fees from Regulus Therapeutics as a board member, outside the submitted work.
Funders:
Funding AgencyGrant Number
Nutricia Research and the Dutch Technology Foundation STW11676
Netherlands Organization for Scientific Research (NWO)UNSPECIFIED
Ministry of Economic AffairsUNSPECIFIED
Ministry of Science and Technology (China)UNSPECIFIED
National Natural Science Foundation of ChinaUNSPECIFIED
Subject Keywords:development, metabolic control, miRNA, nutrition, pathology, signalling
Issue or Number:2
Record Number:CaltechAUTHORS:20150720-140634045
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150720-140634045
Official Citation:Nolte-‘t Hoen EN, Van Rooij E, Bushell M, Zhang C-Y, Dashwood R, James WPT, Harris C, Baltimore D (Utrecht University, Utrecht, The Netherlands; Hubrecht Institute, Koninklijke Nederlandse Academie van Wetenschappen (KNAW), University Medical Center Utrecht, Utrecht, The Netherlands; University of Leicester, Leicester, UK; Jiangsu Engineering Research Center for microRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China; Center for Epigenetics and Disease Prevention, Institute of Biosciences & Technology, Texas A&M Health Science Center, Houston, TX, USA; London School of Hygiene and Tropical Medicine, London, UK; National Cancer Institute, Center for Cancer Research, National Institutes of Health, Bethesda, MD, USA; and California Institute of Technology, Pasadena, CA, USA) The role of microRNA in nutritional control. (Review) J Intern Med 2015; 278: 99–109.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:58950
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:20 Jul 2015 22:38
Last Modified:03 Oct 2019 08:41

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