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Flexible micro sensor for intravascular vulnerable plaque diagnostic with electrical impedance spectroscopy

Zhang, Xiaoxiao and Xu, Lei and Lee, Juhyun and Li, Rongsong and Liu, Yang and Shapero, Aubrey and Hsiai, Tzung K. and Tai, Yu-Chong (2015) Flexible micro sensor for intravascular vulnerable plaque diagnostic with electrical impedance spectroscopy. In: 10th IEEE International Conference on Nano/Micro Engineered and Molecular Systems. IEEE , Piscataway, NJ, pp. 243-247.

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Studies have shown emerging evidence that rupture of coronary plaque containing a lipid-rich core with subsequent thrombus formation is the most frequent mechanism by which atherosclerosis leads to the acute ischaemic syndromes of unstable angina, acute myocardial infarction, and often times, sudden cardiac death. However, since the lumen is not significantly blocked in these cases, such “vulnerable” plaques show noncritical stenosis in X-ray angiography and Intravascular Ultrasound (IVUS), tools currently available to diagnose coronary artery disease. The ability to distinguish such rupture-prone vulnerable plaques remains largely lacking. Therefore it is of great clinical interest to find improved diagnostic techniques to identify and localize such rupture-prone plaques. On the other hand, lipid has significantly lower electrical impedance than the rest of the vessel components in certain frequency bands [1]. We show in this paper that electrical impedance spectroscopy (EIS) technique can be useful to effectively distinguish plaques with such lipid cores. We include in this paper the design rationale of a four electrode EIS sensor and the measurement results between 1 Hz to 300 KHz of ex-vivo mouse aortas with plaque lesions. The impedance modulus over 200 Hz-100 KHz show consistent elevated values 2-5 times higher than their proximity control sites in all three individual mice. The promising ex-vivo EIS results show promising potential for a reliable unstable plaque diagnostic tool for in-vivo catheter integrated intravascular micro EIS sensors.

Item Type:Book Section
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URLURL TypeDescription DOIArticle
Liu, Yang0000-0002-8155-9134
Hsiai, Tzung K.0000-0003-1734-0792
Tai, Yu-Chong0000-0001-8529-106X
Additional Information:© 2015 IEEE.
Record Number:CaltechAUTHORS:20150722-080523739
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Official Citation:Xiaoxiao Zhang; Lei Xu; Juhyun Lee; Rongsong Li; Yang Liu; Shapero, A.; Tzung Hsiai; Yu-Chong Tai, "Flexible micro sensor for intravascular vulnerable plaque diagnostic with electrical impedance spectroscopy," Nano/Micro Engineered and Molecular Systems (NEMS), 2015 IEEE 10th International Conference on , vol., no., pp.243,247, 7-11 April 2015 doi: 10.1109/NEMS.2015.7147419 URL:
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:58976
Deposited By: Tony Diaz
Deposited On:22 Jul 2015 17:02
Last Modified:25 Nov 2019 23:42

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