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Intrinsic Frequency and the Single Wave Biopsy: Implications for Insulin Resistance

Petrasek, Danny and Pahlevan, Niema M. and Tavallali, Peyman and Rinderknecht, Derek G. and Gharib, Morteza (2015) Intrinsic Frequency and the Single Wave Biopsy: Implications for Insulin Resistance. Journal of Diabetes Science and Technology, 9 (6). pp. 1246-1252. ISSN 1932-2968. PMCID PMC4667296.

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Insulin resistance is the hallmark of classical type II diabetes. In addition, insulin resistance plays a central role in metabolic syndrome, which astonishingly affects 1 out of 3 adults in North America. The insulin resistance state can precede the manifestation of diabetes and hypertension by years. Insulin resistance is correlated with a low-grade inflammatory condition, thought to be induced by obesity as well as other conditions. Currently, the methods to measure and monitor insulin resistance, such as the homeostatic model assessment and the euglycemic insulin clamp, can be impractical, expensive, and invasive. Abundant evidence exists that relates increased pulse pressure, pulse wave velocity (PWV), and vascular dysfunction with insulin resistance. We introduce a potential method of assessing insulin resistance that relies on a novel signal-processing algorithm, the intrinsic frequency method (IFM). The method requires a single pulse pressure wave, thus the term “wave biopsy.”

Item Type:Article
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URLURL TypeDescription Material CentralArticle
Gharib, Morteza0000-0002-2204-9302
Additional Information:© 2015 Diabetes Technology Society. Published online before print July 16, 2015. Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. Funding: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: NMP was supported by an American Heart Association grant.
Funding AgencyGrant Number
American Heart AssociationUNSPECIFIED
Subject Keywords:aortic rigidity, insulin resistance, pulse wave velocity, time frequency analysis, inflammation
Issue or Number:6
PubMed Central ID:PMC4667296
Record Number:CaltechAUTHORS:20150728-142921567
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Official Citation:Danny Petrasek, Niema M. Pahlevan, Peyman Tavallali, Derek G. Rinderknecht, and Morteza Gharib Intrinsic Frequency and the Single Wave Biopsy: Implications for Insulin Resistance J Diabetes Sci Technol November 2015 9: 1246-1252, first published on July 16, 2015 doi:10.1177/1932296815588108
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:59040
Deposited By: Tony Diaz
Deposited On:28 Jul 2015 21:43
Last Modified:03 Oct 2019 08:42

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