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A Neurospora mutant deficient in the enzymatic synthesis of tryptophan

Mitchell, Herschel K. and Lein, Joseph (1948) A Neurospora mutant deficient in the enzymatic synthesis of tryptophan. Journal of Biological Chemistry, 175 (1). pp. 481-482. ISSN 0021-9258.

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Until recently there has been no demonstrated case in Neurospora in which the loss of activity of an essential enzyme could be attributed to gene mutation. It has been assumed from indirect evidence1 that gene mutations do cause such losses and thereby result in “blocks” of essential biochemical reactions. The products of the “blocked” reactions thus become essential growth substances for the mutants. The first success in obtaining direct evidence to support the above assumption has been attained by Wagner and Guirard in studies on the enzymatic synthesis of pantothenic acid by cell-free extracts of Neurospora.

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Additional Information:© 1948 American Society for Biochemistry and Molecular Biology. Received for publication, June 23, 1948. This work was supported in part by a grant from the Rockefeller Foundation, and in part under contract with the Office of Naval Research, United States Navy Department. We are indebted to Dr. I. C. Gunsalus for the pyridoxal phosphate used.
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Rockefeller FoundationUNSPECIFIED
Office of Naval Research (ONR)UNSPECIFIED
Issue or Number:1
Record Number:CaltechAUTHORS:20150811-111645768
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Official Citation:Herschel K. Mitchell and Joseph Lein A NEUROSPORA MUTANT DEFICIENT IN THE ENZYMATIC SYNTHESIS OF TRYPTOPHAN J. Biol. Chem. 1948 175: 481-482.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:59397
Deposited By: George Porter
Deposited On:11 Aug 2015 19:47
Last Modified:03 Oct 2019 08:46

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