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Studies on the respiratory system of the poky strain of Neurospora

Tissieres, Alfred and Mitchell, Herschel K. and Haskins, Francis A. (1953) Studies on the respiratory system of the poky strain of Neurospora. Journal of Biological Chemistry, 205 (1). pp. 423-33. ISSN 0021-9258.

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It was shown recently that the poky strain of Neurospora accumulates large amounts of cytochrome c, but is deficient in cytochromes a and b and thus in cytochrome oxidase and succinic acid oxidase activities (1). These findings, which suggest that respiration in poky does not utilize the cytochrome system, led to a study of the respiratory system of poky compared with that of wild type. The experiments reported here are concerned with the effects of the inhibitors cyanide and azide on the respiration of intact mycelium of poky and wild type, the oxygen uptake of cell-free extracts in the oxidation of their endogenous substrates, the cofactor requirement for this oxidation, and the effects of azide and of oxygen tension. Evidence presented confirms that, in poky, respiration does not depend upon the cytochromes, but upon another terminal oxidase system in which flavin-adenine dinucleotide (FAD) enzymes appear to be concerned.

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Additional Information:© 1953 American Society for Biochemistry and Molecular Biology. (Received for publication, May 8, 1953) These investigations were supported by funds from the Rockefeller Foundation, the Williams-Waterman Fund for the Combat of Dietary Diseases, and by funds from the Atomic Energy Commission administered through contract with the Office of Naval Research, contract No. N-6-onr-244, Task Order 5.
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Rockefeller FoundationUNSPECIFIED
Williams-Waterman Fund for the Combat of Dietary DiseasesUNSPECIFIED
Atomic Energy CommissionUNSPECIFIED
Office of Naval Research (ONR)N-6-onr-244
Issue or Number:1
Record Number:CaltechAUTHORS:20150811-122036565
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:59415
Deposited By: George Porter
Deposited On:11 Aug 2015 20:39
Last Modified:03 Oct 2019 08:46

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