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Peptide separation by two-dimensional chromatography and electrophoresis

Katz, Arnold M. and Dreyer, William J. and Anfinsen, Christian B. (1959) Peptide separation by two-dimensional chromatography and electrophoresis. Journal of Biological Chemistry, 234 (11). pp. 2897-2900. ISSN 0021-9258.

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The separation of peptides from controlled proteolytic digests by two-dimensional paper chromatography and electrophoresis is finding wide application to studies of protein structure. With this method it is possible to compare digestion mixtures from different proteins and to detect differences as slight as the replacement of a single amino acid. Such differences are of importance in the comparison of homologous proteins from different animal and plant species, and in the study of genetically determined changes in protein structure, such as those resulting from a single gene mutation.

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Additional Information:© 1959 American Society for Biochemistry and Molecular Biology. (Received for publication, June 25, 1959) The authors would like to thank Dr. Edgar Haber and Mr. Richard Stroud for their help in the design and construction of the Lucite tanks.
Issue or Number:11
Record Number:CaltechAUTHORS:20150811-123906130
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Official Citation:Peptide Separation by Two-dimensional Chromatography and Electrophoresis Arnold M. Katz, William J. Dreyer, and Christian B. Anfinsen J. Biol. Chem. 1959 234: 2897-2900.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:59417
Deposited By: George Porter
Deposited On:11 Aug 2015 20:55
Last Modified:03 Oct 2019 08:46

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