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Reticular Stimulation and Chlorpromazine

Phillips, M. I. and Bradley, P. B. and Kornetsky, C. and Eliasson, M. (1970) Reticular Stimulation and Chlorpromazine. Science, 168 (3935). pp. 1122-1123. ISSN 0036-8075.

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Based on the hypothesis that schizophrenics are overaroused as a result of long-term activation of the brainstem reticular formation (J), Kornetsky and Eliasson proposed that animals electrically stimulated in the reticular formation are overaroused in a similar fashion (2). They postulated an "inverted U" model in which overarousal moves subjects beyond an optimum level of performance and chlorpromazine keeps subjects before the optimum point; therefore the drug reduces the overarousal effects and produces improved performance.

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Additional Information:© 1970 American Association for the Advancement of Science. Received 12 November 1969; revised 22 January 1970. Supported by the Medical Research Council of Great Britain. The experiments were carried out in the M.R.C. Neuropharmacology Research Unit. This comment was written while M.I.P. was supported by a PHS grant to Dr. J. Olds (GM-02031). We thank Dr. Olds for his support.
Funding AgencyGrant Number
Medical Research Council (UK)UNSPECIFIED
US Public Health Service (USPHS)GM-02031
Issue or Number:3935
Record Number:CaltechAUTHORS:20150812-141246584
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Official Citation:Reticular Stimulation and Chlorpromazine M. I. Phillips, P. B. Bradley, Conan Kornetsky, and Mona Eliasson Science 29 May 1970: 168 (3935), 1122-1123. [DOI:10.1126/science.168.3935.1122]
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:59451
Deposited By: Tony Diaz
Deposited On:12 Aug 2015 22:37
Last Modified:03 Oct 2019 08:47

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