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Lens specification is the ground state of all sensory placodes, from which FGF promotes olfactory identity

Bailey, Andrew P. and Bhattacharyya, Sujata and Bronner-Fraser, Marianne and Streit, Andrea (2006) Lens specification is the ground state of all sensory placodes, from which FGF promotes olfactory identity. Developmental Cell, 11 (4). pp. 505-17. ISSN 1534-5807. doi:10.1016/j.devcel.2006.08.009.

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The sense organs of the vertebrate head comprise structures as varied as the eye, inner ear, and olfactory epithelium. In the early embryo, these assorted structures share a common developmental origin within the preplacodal region and acquire specific characteristics only later. Here we demonstrate a fundamental similarity in placodal precursors: in the chick all are specified as lens prior to acquiring features of specific sensory or neurogenic placodes. Lens specification becomes progressively restricted in the head ectoderm, initially by FGF and subsequently by signals derived from migrating neural crest cells. We show that FGF8 from the anterior neural ridge is both necessary and sufficient to promote olfactory fate in adjacent ectoderm. Our results reveal that placode precursors share a common ground state as lens and progressive restriction allows the full range of placodal derivatives to form.

Item Type:Article
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URLURL TypeDescription Data
Bronner-Fraser, Marianne0000-0003-4274-1862
Streit, Andrea0000-0001-7664-7917
Additional Information:© 2006 Elsevier. We thank Sharon Pudaruth for excellent technical assistance and Claudio Stern for critical comments on the manuscript. This work was funded by grant USPHS DE16459 to M.B.-F., and by a Fight for Sight studentship and a BBSRC project grant (D010659/1) to A.S.
Funding AgencyGrant Number
Fight for SightUNSPECIFIED
Biotechnology and Biological Sciences Research Council (BBSRC)D010659/1
Subject Keywords:DEVBIO
Issue or Number:4
Record Number:CaltechAUTHORS:20150813-133335246
Persistent URL:
Official Citation:Andrew P. Bailey, Sujata Bhattacharyya, Marianne Bronner-Fraser, Andrea Streit, Lens Specification Is the Ground State of All Sensory Placodes, from which FGF Promotes Olfactory Identity, Developmental Cell, Volume 11, Issue 4, October 2006, Pages 505-517, ISSN 1534-5807, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:59501
Deposited By: George Porter
Deposited On:13 Aug 2015 21:37
Last Modified:10 Nov 2021 22:21

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