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The synthesis of potential antimalarials; derivatives of α, γ-dihydroxy-β, β-dimethyl-N-ethylbutyramide

Senear, A. E. and Rapport, M. M. and Koepfli, J. B. (1947) The synthesis of potential antimalarials; derivatives of α, γ-dihydroxy-β, β-dimethyl-N-ethylbutyramide. Journal of Biological Chemistry, 167 (1). pp. 229-34. ISSN 0021-9258.

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In 1943 it became known (1) that pantoyltaurylamide (SN 3279) showed antimalarial activity when administered intravenously to chicks infected with Plasmodium gallinaceum. When subsequently phenyl pantothenone (I) (SN 12610), prepared by Woolley and Collyer (2), was tested and shown to possess activity when given orally, it was decided to examine compounds which might be regarded as sulfur analogues of I. Accordingly l-pantolactone was condensed with a series of amines to give the five derivatives of butyramide II to VI.

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Additional Information:© 1947 American Society for Biochemistry and Molecular Biology. (Received for publication, September 17, 1946) The work described in this paper was done under a contract, recommended by Committee on Medical Research, between the Office of Scientific Research and Development and the California Institute of Technology.
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Office of Scientific Research and DevelopmentUNSPECIFIED
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Caltech Gates and Crellin Laboratories of Chemistry1092
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ID Code:59674
Deposited By: George Porter
Deposited On:18 Aug 2015 16:50
Last Modified:03 Oct 2019 08:49

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