CaltechAUTHORS
  A Caltech Library Service

The synthesis of potential antimalarials; derivatives of α, γ-dihydroxy-β, β-dimethyl-N-ethylbutyramide

Senear, A. E. and Rapport, M. M. and Koepfli, J. B. (1947) The synthesis of potential antimalarials; derivatives of α, γ-dihydroxy-β, β-dimethyl-N-ethylbutyramide. Journal of Biological Chemistry, 167 (1). pp. 229-34. ISSN 0021-9258. https://resolver.caltech.edu/CaltechAUTHORS:20150817-165923987

Full text is not posted in this repository. Consult Related URLs below.

Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:20150817-165923987

Abstract

In 1943 it became known (1) that pantoyltaurylamide (SN 3279) showed antimalarial activity when administered intravenously to chicks infected with Plasmodium gallinaceum. When subsequently phenyl pantothenone (I) (SN 12610), prepared by Woolley and Collyer (2), was tested and shown to possess activity when given orally, it was decided to examine compounds which might be regarded as sulfur analogues of I. Accordingly l-pantolactone was condensed with a series of amines to give the five derivatives of butyramide II to VI.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://www.jbc.org/content/167/1/229.absPublisherArticle
Additional Information:© 1947 American Society for Biochemistry and Molecular Biology. (Received for publication, September 17, 1946) The work described in this paper was done under a contract, recommended by Committee on Medical Research, between the Office of Scientific Research and Development and the California Institute of Technology.
Funders:
Funding AgencyGrant Number
Office of Scientific Research and DevelopmentUNSPECIFIED
Other Numbering System:
Other Numbering System NameOther Numbering System ID
Caltech Gates and Crellin Laboratories of Chemistry1092
Issue or Number:1
Record Number:CaltechAUTHORS:20150817-165923987
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150817-165923987
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:59674
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:18 Aug 2015 16:50
Last Modified:03 Oct 2019 08:49

Repository Staff Only: item control page