Guidestar-assisted wavefront-shaping methods for focusing light into biological tissue

Horstmeyer, Roarke and Ruan, Haowen and Yang, Changhuei (2015) Guidestar-assisted wavefront-shaping methods for focusing light into biological tissue. Nature Photonics, 9 (9). pp. 563-571. ISSN 1749-4885. PMCID PMC4900467. https://resolver.caltech.edu/CaltechAUTHORS:20150909-110929870

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Abstract

In the field of biomedical optics, optical scattering has traditionally limited the range of imaging within tissue to a depth of one millimetre. A recently developed class of wavefront-shaping techniques now aims to overcome this limit and achieve diffraction-limited control of light beyond one centimetre. By manipulating the spatial profile of an optical field before it enters a scattering medium, it is possible to create a micrometre-scale focal spot deep within tissue. To successfully operate in vivo, these wavefront-shaping techniques typically require feedback from within the biological sample. This Review summarizes recently developed 'guidestar' mechanisms that provide feedback for intra-tissue focusing. Potential applications of guidestar-assisted focusing include optogenetic control over neurons, targeted photodynamic therapy and deep tissue imaging.

Item Type:

Article

Related URLs:

URL	URL Type	Description
http://dx.doi.org/10.1038/NPHOTON.2015.140	DOI	Article
http://rdcu.be/dTWA	Publisher	Free ReadCube access
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900467/	PubMed Central	Article

ORCID:

Author	ORCID
Horstmeyer, Roarke	0000-0002-2480-9141
Ruan, Haowen	0000-0002-4917-4509
Yang, Changhuei	0000-0001-8791-0354

Additional Information:

© 2015 Macmillan Publishers Limited. Received 25 March 2015; Accepted 06 July 2015; Published online 27 August 2015. We thank M. Jang, E. Zhou, B. Judkewitz, I. M. Vellekoop, J. Brake, H. Deng and M. Harfouche for helpful feedback during manuscript preparation. This work is supported by the National Institutes of Health (1DP2OD007307-01), the National Institutes of Health BRAIN Initiative (1U01NS090577-01) and a GIST-Caltech Collaborative Research Proposal (CG2012). All authors contributed equally to this work. The authors declare no competing financial interests.

Funders:

Funding Agency	Grant Number
NIH	1DP2OD007307-01
NIH	1U01NS090577-01
GIST-Caltech Research Collaboration	CG2012

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PubMed Central ID:

PMC4900467

Record Number:

CaltechAUTHORS:20150909-110929870

Persistent URL:

https://resolver.caltech.edu/CaltechAUTHORS:20150909-110929870

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No commercial reproduction, distribution, display or performance rights in this work are provided.

ID Code:

60124

Collection:

CaltechAUTHORS

Deposited By:

Tony Diaz

Deposited On:

09 Sep 2015 20:52

Last Modified:

20 Nov 2020 22:35

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