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Guidestar-assisted wavefront-shaping methods for focusing light into biological tissue

Horstmeyer, Roarke and Ruan, Haowen and Yang, Changhuei (2015) Guidestar-assisted wavefront-shaping methods for focusing light into biological tissue. Nature Photonics, 9 (9). pp. 563-571. ISSN 1749-4885. PMCID PMC4900467.

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In the field of biomedical optics, optical scattering has traditionally limited the range of imaging within tissue to a depth of one millimetre. A recently developed class of wavefront-shaping techniques now aims to overcome this limit and achieve diffraction-limited control of light beyond one centimetre. By manipulating the spatial profile of an optical field before it enters a scattering medium, it is possible to create a micrometre-scale focal spot deep within tissue. To successfully operate in vivo, these wavefront-shaping techniques typically require feedback from within the biological sample. This Review summarizes recently developed 'guidestar' mechanisms that provide feedback for intra-tissue focusing. Potential applications of guidestar-assisted focusing include optogenetic control over neurons, targeted photodynamic therapy and deep tissue imaging.

Item Type:Article
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URLURL TypeDescription ReadCube access CentralArticle
Horstmeyer, Roarke0000-0002-2480-9141
Ruan, Haowen0000-0002-4917-4509
Yang, Changhuei0000-0001-8791-0354
Additional Information:© 2015 Macmillan Publishers Limited. Received 25 March 2015; Accepted 06 July 2015; Published online 27 August 2015. We thank M. Jang, E. Zhou, B. Judkewitz, I. M. Vellekoop, J. Brake, H. Deng and M. Harfouche for helpful feedback during manuscript preparation. This work is supported by the National Institutes of Health (1DP2OD007307-01), the National Institutes of Health BRAIN Initiative (1U01NS090577-01) and a GIST-Caltech Collaborative Research Proposal (CG2012). All authors contributed equally to this work. The authors declare no competing financial interests.
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GIST-Caltech Research CollaborationCG2012
Issue or Number:9
PubMed Central ID:PMC4900467
Record Number:CaltechAUTHORS:20150909-110929870
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:60124
Deposited By: Tony Diaz
Deposited On:09 Sep 2015 20:52
Last Modified:20 Nov 2020 22:35

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