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Click chemistry surface functionalization for resonant micro-cavity sensors

Armani, Andrea M. and Alabi, Akinleye C. and Davis, Mark E. and Flagan, Richard C. and Fraser, Scott E. (2012) Click chemistry surface functionalization for resonant micro-cavity sensors. Patent number: US8092855B2. https://resolver.caltech.edu/CaltechAUTHORS:20150910-084810058

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Abstract

Micro-cavity resonant sensors have outer surfaces that are functionalized using click chemistry, e.g., involving a cycloaddition reaction of an alkyne functional group and an azide functional group. A first polymer linking element binds to an outer surface of the micro-cavity and has an azide functional group, which bonds to an alkyne functional group of a second polymer linking element as a result of a cycloaddition reaction. A functionalization element such as an antibody, antigen or protein for sensing a target molecule is bound to the second linking element.


Item Type:Patent
Related Patents:US 9,116,128 B2, US20090214755A1
Patent Classification:Current U.S. Class: 427/2.13; 427/162; 427/2.1; 427/299; 427/331; 435/6.19. Current CPC Class: G01N 21/7746 (20130101); G01N 33/54353 (20130101); G01N 2021/7789 (20130101). Current International Class: G01N 1/28 (20060101).
Patent Assignee:California Institute of Technology
Related URLs:
URLURL TypeDescription
https://patents.google.com/patent/US8092855B2/enPatentGoogle Patents site
http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=/netahtml/PTO/search-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN/8092855PatentU.S. Patent Office
ORCID:
AuthorORCID
Armani, Andrea M.0000-0001-9890-5104
Flagan, Richard C.0000-0001-5690-770X
Fraser, Scott E.0000-0002-5377-0223
Additional Information:Publication number US8092855B2. Publication type Grant. Application number 12/324,605. Publication date January 10, 2012 . Filing date November 26, 2008. Priority date November 28, 2007. Government Interests: STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH: The U.S. Government has certain rights in this invention pursuant to Grant No. HR 0011-04-1-0032 awarded by DARPA. Parent Case Text: RELATED APPLICATION DATA: This application claims the benefit under 35 U.S.C. .sctn.119 of U.S. Provisional Application Ser. No. 61/004,580, filed Nov. 28, 2007, the contents of which are incorporated herein by reference as though set forth in full. This application may also be related to the following applications and patent, the contents of which are also incorporated herein by reference as though set forth in full: U.S. application Ser. No. 12/243,580, filed on Oct. 1, 2008; U.S. application Ser. No. 11/733,480, filed on Apr. 10, 2007; U.S. application Ser. No. 11/016,067, filed on Dec. 17, 2004; and U.S. application Ser. No. 10/678,354, filed on Oct. 2, 2003, and U.S. Pat. No. 6,583,399, issued on Jun. 24, 2003.
Funders:
Funding AgencyGrant Number
Defense Advanced Research Projects Agency (DARPA)HR 0011-04-1-0032
Record Number:CaltechAUTHORS:20150910-084810058
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150910-084810058
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:60162
Collection:CaltechAUTHORS
Deposited By: Irina Meininger
Deposited On:25 Feb 2016 00:39
Last Modified:03 Oct 2019 08:54

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