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Click chemistry surface functionalization for resonant micro-cavity sensors

Armani, Andrea M. and Alabi, Akinleye C. and Davis, Mark E. and Flagan, Richard C. and Fraser, Scott E. (2015) Click chemistry surface functionalization for resonant micro-cavity sensors. Patent number: US 9,116,128 B2.

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Micro-cavity resonant sensors have outer surfaces that are functionalized using click chemistry, e.g., involving a cycloaddition reaction of an alkyne functional group and an azide functional group. A first polymer linking element binds to an outer surface of the micro-cavity and has an azide functional group, which bonds to an alkyne functional group of a second polymer linking element as a result of a cycloaddition reaction. A functionalization element such as an antibody, antigen or protein for sensing a target molecule is bound to the second linking element.

Item Type:Patent
Related Patents:US8092855B2, US20090214755A1
Patent Classification:Current CPC Class: G01N 21/7746 (20130101); G01N 33/54353 (20130101); G01N 2021/7789 (20130101). Current International Class: G01N 33/547 (20060101); G01N 21/77 (20060101); G01N 33/543 (20060101); G01N 33/553 (20060101).
Patent Assignee:California Institute of Technology
Related URLs:
URLURL TypeDescription Patents Site Patent Office (European Patent Office)
Armani, Andrea M.0000-0001-9890-5104
Davis, Mark E.0000-0001-8294-1477
Flagan, Richard C.0000-0001-5690-770X
Fraser, Scott E.0000-0002-5377-0223
Additional Information:Publication number US 9,116,128 B2. Publication type Grant. Application number US20120107177A1. Publication date August 25, 2015. Prior publication date May 3, 2012. Filing date January 9, 2012. Priority date Nov 28, 2007. Government Interests: The U.S. Government has certain rights in this invention pursuant to Grant No. HR 0011-04-1-0032 awarded by DARPA. Parent Case Text: The present application is a continuation of U.S. patent application Ser. No. 12/324,605, filed on Nov. 26, 2008, which claims the benefit under 35 U.S.C. .sctn.119 of U.S. Provisional Patent Application Ser. No. 61/004,580, filed on Nov. 28, 2007, the contents of which are incorporated herein by reference as though set forth in full. This application may also be related to the following applications and patent, the contents of which are also incorporated herein by reference as though set forth in full: U.S. application Ser. No. 12/243,580, filed on Oct. 1, 2008; U.S. application Ser. No. 11/733,480, filed on Apr. 10, 2007; U.S. application Ser. No. 11/016,067, filed on Dec. 17, 2004; and U.S. application Ser. No. 10/678,354, filed on Oct. 2, 2003, and U.S. Pat. No. 6,583,399, issued on Jun. 24, 2003.
Funding AgencyGrant Number
Defense Advanced Research Projects Agency (DARPA)HR 0011-04-1-0032
Record Number:CaltechAUTHORS:20150910-091259402
Persistent URL:
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:60168
Deposited By: Irina Meininger
Deposited On:02 Dec 2015 19:15
Last Modified:10 Mar 2020 17:40

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