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Protein degradation: Prime time for PROTACs

Deshaies, Raymond J. (2015) Protein degradation: Prime time for PROTACs. Nature Chemical Biology, 11 (9). pp. 634-635. ISSN 1552-4450. https://resolver.caltech.edu/CaltechAUTHORS:20150911-085528272

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Abstract

PROTACs are heterobifunctional small molecules that simultaneously bind a target protein and a ubiquitin ligase, enabling ubiquitination and degradation of the target. Major progress in developing potent and specific PROTACs has recently been reported, invigorating prospects for novel PROTAC-based therapies.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1038/nchembio.1887DOIArticle
http://www.nature.com/nchembio/journal/v11/n9/full/nchembio.1887.htmlPublisherArticle
http://rdcu.be/dUUjPublisherFree ReadCube access
ORCID:
AuthorORCID
Deshaies, Raymond J.0000-0002-3671-9354
Additional Information:© 2015 Macmillan Publishers Limited. Published online 18 August 2015. R.J.D. is co-founder of a company (Cleave Biosciences) that is developing therapeutics based on targeting enzymes in the ubiquitin-proteasome pathway. R.J.D. also holds stock in Cleave Biosciences and serves as a consultant and member of their Scientific Advisory Board.
Issue or Number:9
Record Number:CaltechAUTHORS:20150911-085528272
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150911-085528272
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:60179
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:11 Sep 2015 17:37
Last Modified:03 Oct 2019 08:54

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