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Exploring the Structure of Human Defensive Responses from Judgments of Threat Scenarios

Harrison, Laura A. and Ahn, Curie and Adolphs, Ralph (2015) Exploring the Structure of Human Defensive Responses from Judgments of Threat Scenarios. PLoS ONE, 10 (8). Art. No. e0133682. ISSN 1932-6203. PMCID PMC4546605. https://resolver.caltech.edu/CaltechAUTHORS:20150911-151403579

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Abstract

How humans react to threats is a topic of broad theoretical importance, and also relevant for understanding anxiety disorders. Many animal threat reactions exhibit a common structure, a finding supported by human evaluations of written threat scenarios that parallel patterns of rodent defensive behavior to actual threats. Yet the factors that underlie these shared behavioral patterns remain unclear. Dimensional accounts rooted in Darwin’s conception of antithesis explain many defensive behaviors. Across species, it is also clear that defensive reactions depend on specific situational factors, a feature long emphasized by psychological appraisal theories. Our study sought to extend prior investigations of human judgments of threat to a broader set of threats, including natural disasters, threats from animals, and psychological (as opposed to physical) threats. Our goal was to test whether dimensional and specific patterns of threat evaluation replicate across different threat classes. 85 healthy adult subjects selected descriptions of defensive behaviors that indicated how they would react to 29 threatening scenarios. Scenarios differed with respect to ten factors, e.g., perceived dangerousness or escapability. Across scenarios, we correlated these factor ratings with the pattern of defensive behaviors subjects endorsed. A decision tree hierarchically organized these correlation patterns to successfully predict each scenario’s most common reaction, both for the original sample of subjects and a separate replication group (n = 22). At the top of the decision tree, degree of dangerousness interacted with threat type (physical or psychological) to predict dimensional approach/avoidance behavior. Subordinate nodes represented specific defensive responses evoked by particular contexts. Our ecological approach emphasizes the interplay of situational factors in evoking a broad range of threat reactions. Future studies could test predictions made by our results to help understand pathological threat processing, such as seen in anxiety disorders, and could begin to test underlying neural mechanisms.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1371/journal.pone.0133682DOIArticle
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0133682PublisherArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546605/PubMed CentralArticle
ORCID:
AuthorORCID
Adolphs, Ralph0000-0002-8053-9692
Additional Information:© 2015 Harrison et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Received: May 5, 2015; Accepted: June 30, 2015; Published: August 21, 2015. Data Availability Statement: All raw data is hosted on the Open Science Framework at https://osf.io/wbqa5/. All relevant experimental and analysis details are included in the paper and its Supporting Information files. Any desired further clarifications, information, or materials can be furnished by the corresponding author upon request. Funding: RA received funding from the National Institute of Mental Health (http://www.nimh.nih.gov) for grants numbered R01MH080721 and P50MH094258, which funded this work. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing Interests: The authors have declared no competing interests exist. We dedicate this article to the late Robert J. Blanchard, a pioneer in the field. Author Contributions: Conceived and designed the experiments: LAH CA RA. Performed the experiments: LAH CA. Analyzed the data: LAH CA RA. Wrote the paper: LAH CA RA.
Funders:
Funding AgencyGrant Number
NIHR01MH080721
NIHP50MH094258
National Institute of Mental Health (NIMH)UNSPECIFIED
Issue or Number:8
PubMed Central ID:PMC4546605
Record Number:CaltechAUTHORS:20150911-151403579
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150911-151403579
Official Citation:Harrison LA, Ahn C, Adolphs R (2015) Exploring the Structure of Human Defensive Responses from Judgments of Threat Scenarios. PLoS ONE 10(8): e0133682. doi:10.1371/journal.pone.0133682
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:60204
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:11 Sep 2015 22:40
Last Modified:03 Oct 2019 08:54

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