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An Enhanced Default Approach Bias Following Amygdala Lesions in Humans

Harrison, Laura A. and Hurlemann, René and Adolphs, Ralph (2015) An Enhanced Default Approach Bias Following Amygdala Lesions in Humans. Psychological Science, 26 (10). pp. 1543-1555. ISSN 0956-7976 . PMCID PMC4607547. https://resolver.caltech.edu/CaltechAUTHORS:20150914-084700448

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Abstract

Approach and avoidance constitute a basic dimension of all animal behavior. Although a large number of studies have investigated approach and avoidance elicited by specific sensory stimuli, comparatively little is known about default approach biases when stimulus information is absent or reduced. The amygdala is well known to contribute to approach and avoidance behaviors in response to specific sensory stimuli; we tested whether the amygdala’s role might extend to situations in which stimulus information is reduced. In a novel task, 3 patients with rare bilateral amygdala lesions (and control subjects) made approach-related judgments about photos of intact faces and of the same faces with all internal facial features occluded. Direct comparisons of the judgments of these stimuli isolated a default bias. The patients showed a greater tendency than the control subjects to rate occluded faces as more approachable than whole faces. These findings suggest that the amygdala’s role in approach behavior extends beyond responses to specific stimuli.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1177/0956797615583804DOIArticle
http://pss.sagepub.com/content/26/10/1543PublisherArticle
http://pss.sagepub.com/content/26/10/1543/suppl/DC1PublisherSupplemental Material
https://osf.io/8cktf/OrganizationData
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607547/PubMed CentralArticle
ORCID:
AuthorORCID
Adolphs, Ralph0000-0002-8053-9692
Additional Information:© 2015 The Author(s). Received 10/6/14; Revision accepted 4/1/15. Published online before print September 3, 2015. Author Contributions: L. A. Harrison and R. Adolphs developed the study concept and design. Testing and data collection were performed by L. A. Harrison and R. Hurlemann. L. A. Harrison performed the data analysis and interpretation under the supervision of R. Adolphs. L. A. Harrison drafted the manuscript, and R. Adolphs provided critical revisions. All authors approved the final version of the manuscript for submission. We thank Dirk Scheele, Yoan Mihov, Ronnie Bryan, Mike Tyszka, Julien Dubois, and especially the patients for their assistance. The authors declared that they had no conflicts of interest with respect to their authorship or the publication of this article. This research was funded by grants from the National Institute of Mental Health (Grant P50MH094258), the Gordon and Betty Moore Foundation, and the German Research Foundation (DFG). Supplemental Material: Additional supporting information can be found at http://pss.sagepub.com/content/by/supplemental-data Open Practices: All data have been made publicly available via Open Science Framework and can be accessed at https://osf.io/8cktf/. Task instructions can also be accessed at https://osf.io/8cktf/. Because of confidentiality concerns, the photographs used as stimuli are not available at Open Science Framework, but they can be obtained for research use by contacting Laura A. Harrison, lauraharrison@caltech.edu. The complete Open Practices Disclosure for this article can be found at http://pss.sagepub.com/content/by/supplemental-data. This article has received the badge for Open Data. More information about the Open Practices badges can be found at https://osf.io/tvyxz/wiki/1.%20View%20the%20Badges/ and http://pss.sagepub.com/content/25/1/3.full.
Funders:
Funding AgencyGrant Number
NIHP50MH094258
Gordon and Betty Moore FoundationUNSPECIFIED
Deutsche Forschungsgemeinschaft (DFG)UNSPECIFIED
National Institute of Mental Health (NIMH)UNSPECIFIED
Subject Keywords:amygdala, approach, avoidance, face processing, Urbach-Wiethe disease, lesion, ambiguity, open data
Issue or Number:10
PubMed Central ID:PMC4607547
Record Number:CaltechAUTHORS:20150914-084700448
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150914-084700448
Official Citation:Laura A. Harrison, Rene Hurlemann, and Ralph Adolphs An Enhanced Default Approach Bias Following Amygdala Lesions in Humans Psychological Science October 2015 26: 1543-1555, first published on September 3, 2015 doi:10.1177/0956797615583804
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:60212
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:14 Sep 2015 18:28
Last Modified:03 Oct 2019 08:54

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