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Studies of the binding interactions of cis-diamminedichloroplatinum(II) with amines and nucleosides by nitrogen-15 nuclear magnetic resonance

Nee, Michael and Roberts, John D. (1982) Studies of the binding interactions of cis-diamminedichloroplatinum(II) with amines and nucleosides by nitrogen-15 nuclear magnetic resonance. Biochemistry, 21 (20). pp. 4920-4926. ISSN 0006-2960. http://resolver.caltech.edu/CaltechAUTHORS:20151005-113555194

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Abstract

The ^(15)N chemical shifts and couplings have been measured for several platinum(II)amine complexes. The ^(15)N chemical shift changes found on coordination of azine-type nitrogens to platinum appear to be related to those that occur on protonation of the same nitrogens. Both the ^(15)N chemical shifts and the one-bond ^(l5)N-^(195)Pt coupling constants depend on the nature of the cis and trans ligands. cis-[Pt(NH_3)_2Cl_2](“cis-platinum”) forms a complex with cytidine through N^3. Guanosine becomes bound to platinum of cis- [Pt(NH_3)_2Cl_2] at N7 and at least one other nitrogen. Adenosine appears to bind cis-[Pt(NH_3)_2Cl_2] to at least some degree through N1, N3, N7, and the 6’ -NH_2.


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http://dx.doi.org/10.1021/bi00263a014DOIArticle
http://pubs.acs.org/doi/abs/10.1021/bi00263a014PublisherArticle
Additional Information:© 1982 American Chemical Society. From the Gates and Crellin Laboratories of Chemistry, California Institute of Technology, Pasadena, California 91125. Received February 23, 1982. Contribution No. 6710. Supported by the National Science Foundation and the US. Public Health Service, Research Grant No. GM-11072 from the Division of General Medical Sciences.
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U.S. Public Health Service (USPHS)GM-11072
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Caltech Gates and Crellin Laboratories6710
Record Number:CaltechAUTHORS:20151005-113555194
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20151005-113555194
Official Citation:Studies of the binding interactions of cis-diamminedichloroplatinum(II) with amines and nucleosides by nitrogen-15 nuclear magnetic resonance Michael Nee and John D. Roberts Biochemistry 1982 21 (20), 4920-4926 DOI: 10.1021/bi00263a014
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ID Code:60759
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:05 Oct 2015 21:51
Last Modified:05 Oct 2015 21:51

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