Nee, Michael and Chun, Yu and Squillacote, Michael E. and Roberts, John D. (1982) A ^(15)N nuclear magnetic resonance study of the base-catalyzed NH_2 exchange reactions of acetamide and thioacetamide. Organic Magnetic Resonance, 18 (3). pp. 125-127. ISSN 0030-4921. doi:10.1002/mrc.1270180302. https://resolver.caltech.edu/CaltechAUTHORS:20151005-120248398
Full text is not posted in this repository. Consult Related URLs below.
Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:20151005-120248398
Abstract
The base-catalyzed -NH_2 exchange reactions of acetamide and thioacetamide were studied by ^(15)N nuclear magnetic resonance spectroscopy by the use of line-shape analysis. The ^(15)N NMR spectra of these primary amides at intermediate exchange rates were broad doublets, which indicated that the two amide protons were exchanging at different rates. The line-shape analysis indicated that the ratio of exchange rates was 6 ± 1 for acetamide and 3 ± 1 for thioacetamide.
| Item Type: | Article | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Related URLs: |
| |||||||||
| Additional Information: | © 1982 Heyden & Son Ltd. Received 6 October 1980; accepted (revised) 21 September 1981. This work was supported by the National Science Foundation, and by the Public Health Service, Research Grant No. GM-11072 from the Division of General Medical Sciences. The authors are indebted to Professor Charles Perrin for his suggestion that the ^(15)N spectra could be used to determine these rate ratios. We are also grateful to Professor F. A. L. Anet for help with the use of his site-exchange program. | |||||||||
| Funders: |
| |||||||||
| Other Numbering System: |
| |||||||||
| Issue or Number: | 3 | |||||||||
| DOI: | 10.1002/mrc.1270180302 | |||||||||
| Record Number: | CaltechAUTHORS:20151005-120248398 | |||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20151005-120248398 | |||||||||
| Official Citation: | Nee, M., Chun, Y., Squillacote, M. E. and Roberts, J. D. (1982), A 15N nuclear magnetic resonance study of the base-catalyzed NH2 exchange reactions of acetamide and thioacetamide. Org. Magn. Reson., 18: 125–127. doi: 10.1002/mrc.1270180302 | |||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
| ID Code: | 60764 | |||||||||
| Collection: | CaltechAUTHORS | |||||||||
| Deposited By: | Ruth Sustaita | |||||||||
| Deposited On: | 05 Oct 2015 22:20 | |||||||||
| Last Modified: | 10 Nov 2021 22:38 |
Repository Staff Only: item control page
