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The protonation site of vitamin B_1 as determined from natural-abundance nitrogen-15 nuclear magnetic resonance spectra

Cain, Anne H. and Sullivan, Glenn R. and Roberts, John D. (1977) The protonation site of vitamin B_1 as determined from natural-abundance nitrogen-15 nuclear magnetic resonance spectra. Journal of the American Chemical Society, 99 (19). pp. 6423-6425. ISSN 0002-7863. http://resolver.caltech.edu/CaltechAUTHORS:20151008-070944702

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Abstract

Natural-abundance nitrogen-15 nuclear magnetic resonance spectroscopy has been used to determine the site of protonation in vitamin B_1. Selectively decoupling individual protons of the vitamin in water, D_2O, and ethylene glycol permitted assignment of the nitrogen resonances and thence the determination of the site of protonation, which was found to be N-1 of the pyrimidine ring.


Item Type:Article
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http://dx.doi.org/10.1021/ja00461a040DOIArticle
http://pubs.acs.org/doi/abs/10.1021/ja00461a040PublisherArticle
Additional Information:© 1977 American Chemical Society. Received January 19, 1977. Supported in part by the National Science Foundation and by the Public Health Service, Research Grant 11072 from the division of General Medical Science.
Funders:
Funding AgencyGrant Number
NSFUNSPECIFIED
U.S. Public Health Service (USPHS)GM-11072
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Caltech Gates and Crellin Laboratories of Chemistry5496
Record Number:CaltechAUTHORS:20151008-070944702
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20151008-070944702
Official Citation:The protonation site of vitamin B1 as determined from natural-abundance nitrogen-15 nuclear magnetic resonance spectra Anne H. Cain, Glenn R. Sullivan, and John D. Roberts Journal of the American Chemical Society 1977 99 (19), 6423-6425 DOI: 10.1021/ja00461a040
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:60891
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:08 Oct 2015 18:42
Last Modified:08 Oct 2015 18:42

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