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Requirement of Protein Synthesis for Bacteriophage {varphi}X174 Superinfection Exclusion

Hutchison, Clyde A., III and Sinsheimer, Robert L. (1971) Requirement of Protein Synthesis for Bacteriophage {varphi}X174 Superinfection Exclusion. Journal of Virology, 8 (1). pp. 121-124. ISSN 0022-538X. PMCID PMC356222.

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Within 5 to 10 min at 37 C, bacteria infected by bacteriophage {varphi}X174 acquire the ability to exclude superinfecting {varphi}X particles from reproducing themselves. The superinfecting phage are blocked at a stage prior to synthesis of the parental replicative form molecule; the superinfecting deoxyribonucleic acid remains as intact (infective) single strands. Establishment of superinfection exclusion and its maintenance require protein synthesis.

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Additional Information:© 1971 American Society for Microbiology. Received for publication 2 February 1971 These results are drawn from a thesis submitted by C.A.H. to the California Institute of Technology in partial fulfillment of the requirements for the Ph.D. degree. We thank John E. Newbold for repeated gifts of 32P15ND φXam3. This work was supported by Public Health Service grant GM-13554 from the National Institute of General Medical Sciences.
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Issue or Number:1
PubMed Central ID:PMC356222
Record Number:CaltechAUTHORS:HUTjvir71
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:6096
Deposited By: Archive Administrator
Deposited On:17 Nov 2006
Last Modified:02 Oct 2019 23:29

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