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Integrating multiple sensory systems to modulate neural networks controlling posture

Lavrov, Igor and Gerasimenko, Yury P. and Burdick, Joel W. and Zhong, Hui and Roy, Roland R. and Edgerton, V. Reggie (2015) Integrating multiple sensory systems to modulate neural networks controlling posture. Journal of Neurophysiology, 114 (6). pp. 3306-3314. ISSN 0022-3077. https://resolver.caltech.edu/CaltechAUTHORS:20151012-153837318

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Abstract

In this study we investigated the ability of sensory input to produce tonic responses in hindlimb muscles to facilitate standing in adult spinal rats and tested two hypotheses: 1) whether the spinal neural networks below a complete spinal cord transection can produce tonic reactions by activating different sensory inputs and 2) whether facilitation of tonic and rhythmic responses via activation of afferents and with spinal cord stimulation could engage similar neuronal mechanisms. We used a dynamically controlled platform to generate vibration while weight bearing, epidural stimulation (at spinal cord level S1), and/or tail pinching to determine the postural control responses that can be generated by the lumbosacral spinal cord. We observed that a combination of platform displacement, epidural stimulation, and pinching the tail produces a cumulative effect that progressively enhances tonic responses in the hindlimbs. Tonic responses produced by epidural stimulation alone during standing were represented mainly by monosynaptic responses, whereas the combination of epidural stimulation and tail pinching during standing or epidural stimulation during stepping on a treadmill facilitated bilaterally both monosynaptic and polysynaptic responses. The results demonstrate that tonic muscle activity after complete spinal cord injury can be facilitated by activation of specific combinations of afferent inputs associated with load-bearing proprioception and cutaneous input in the presence of epidural stimulation and indicate whether activation of tonic or rhythmic responses are generated depends on the specific combinations of sources and types of afferents activated in the hindlimb muscles.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1152/jn.00583.2015DOIArticle
http://jn.physiology.org/content/114/6/3306.longPublisherArticle
Additional Information:© 2015 Journal of Neurophysiology. Published 7 October 2015. This research was supported by NIH U01EB15521, R01EB007615 through NIBIB, NINDS, NICD, and Russian Foundation for Basic Research Grants 13-04-01091 and 15-44-02697. Partial support for analysis of the effects of combination of platform reaction and epidural stimulation was provided to IL by Russian Science Foundation (RSF grant No 15-15-20036).
Funders:
Funding AgencyGrant Number
NIHU01EB15521
NIHR01EB007615
National Institute of Biomedical Imaging and Bioengineering (NIBIB)UNSPECIFIED
National Institute of Neurological Disorders and Stroke (NINDS)UNSPECIFIED
National Institute for Communicable Diseases (NICD)UNSPECIFIED
Russian Foundation for Basic Research13-04-01091
Russian Foundation for Basic Research15-44-02697
Russian Science Foundation15-15-20036
Subject Keywords:Spinal cord transection, postural control, locomotion, spinal cord stimulation, vibration
Issue or Number:6
Record Number:CaltechAUTHORS:20151012-153837318
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20151012-153837318
Official Citation:Integrating multiple sensory systems to modulate neural networks controlling posture I. Lavrov, Y. Gerasimenko, J. Burdick, H. Zhong, R. R. Roy, V. R. Edgerton Journal of Neurophysiology Published 1 December 2015 Vol. 114 no. 6, 3306-3314 DOI: 10.1152/jn.00583.2015
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:61019
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:15 Oct 2015 04:55
Last Modified:03 Oct 2019 09:03

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