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Comparison of genes upregulated in metastasis with three C. elegans cell migrations

Kato, Mihoko and Liu, Jonathan and Power, Olivia Box and Upadhyaya, Anand and Yim, John and Sternberg, Paul (2014) Comparison of genes upregulated in metastasis with three C. elegans cell migrations. Molecular Cancer Research, 12 (S11). Art. No. A46. ISSN 1541-7786. doi:10.1158/1557-3125.MODORG-A46.

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Cell migration is an important process occurring during normal animal development but also in the early stages of metastatic cancer when cells invasively migrate out of the primary tumor. It is therefore likely that some of the same genes function in both migrations. Although transcriptional profiling has identified many genes differentially expressed between metastases and primary tumors, we do not understand the function of most of these genes in either normal or disease states. Our goal has been to identify conserved genes used in migration of mammalian metastasis and normal C. elegans development to further characterize their function in both systems. From two published transcriptional profile datasets, we selected genes that were upregulated in metastases compared to primary tumors, and then identified the C. elegans orthologs of those genes to generate a list of 107 genes.

Item Type:Article
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URLURL TypeDescription DOIArticle
Kato, Mihoko0000-0003-3827-8879
Sternberg, Paul0000-0002-7699-0173
Additional Information:© 2014 American Association for Cancer Research.
Issue or Number:S11
Record Number:CaltechAUTHORS:20151013-102856013
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Official Citation:Mihoko Kato, Jonathan Liu, Olivia Box Power, Anand Upadhyaya, John Yim, Paul Sternberg. Comparison of genes upregulated in metastasis with three C. elegans cell migrations. [abstract]. In: Proceedings of the AACR Special Conference: The Translational Impact of Model Organisms in Cancer; Nov 5-8, 2013; San Diego, CA. Philadelphia (PA): AACR; Mol Cancer Res 2014;12(11 Suppl):Abstract nr A46
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:61032
Deposited By: Tony Diaz
Deposited On:15 Oct 2015 03:50
Last Modified:10 Nov 2021 22:43

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