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Single cell phosphoproteomics identifies adaptive network dynamics of mTOR inhibitor resistance and defines effective combination therapy in glioblastoma

Shin, Young Shik and Wei, Wei and Gini, Beatrice and Mischel, Paul and Heath, James (2015) Single cell phosphoproteomics identifies adaptive network dynamics of mTOR inhibitor resistance and defines effective combination therapy in glioblastoma. Clinical Cancer Research, 21 (S4). Art. No. PR09. ISSN 1078-0432. https://resolver.caltech.edu/CaltechAUTHORS:20151020-110744228

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Abstract

Resistance to single-agent targeted cancer therapy is almost universal. Resistance can occur when drug-resistant tumor cell subpopulations expand to drive recurrence in a process akin to Darwinian-type evolution under the selection pressure of the drug. An alternative resistance mechanism is the one in which cancer cells targeted by the inhibitor adapt to that drug, so as to maintain the signal flux through those networks that are required for tumor maintenance and growth. The main goal of this study is to identify the mechanisms of resistance in a targeted therapy by analyzing single cells and to provide a strategy to design a more effective therapy that suppresses resistance.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1158/1557-3265.PMS14-PR09 DOIArticle
http://clincancerres.aacrjournals.org/content/21/4_Supplement/PR09PublisherArticle
ORCID:
AuthorORCID
Wei, Wei0000-0002-1018-7708
Heath, James0000-0001-5356-4385
Additional Information:© 2015 American Association for Cancer Research.
Issue or Number:S4
Record Number:CaltechAUTHORS:20151020-110744228
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20151020-110744228
Official Citation:Young Shik Shin, Wei Wei, Beatrice Gini, Paul Mischel, James Heath. Single cell phosphoproteomics identifies adaptive network dynamics of mTOR inhibitor resistance and defines effective combination therapy in glioblastoma. [abstract]. In: Proceedings of the AACR Precision Medicine Series: Drug Sensitivity and Resistance: Improving Cancer Therapy; Jun 1821, 2014; Orlando, FL. Philadelphia (PA): AACR; Clin Cancer Res 2015;21(4 Suppl): Abstract nr PR09
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:61328
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:20 Oct 2015 18:15
Last Modified:18 Dec 2019 23:35

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