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Atypical Visual Saliency in Autism Spectrum Disorder Quantified through Model-Based Eye Tracking

Wang, Shuo and Jiang, Ming and Duchesne, Xavier Morin and Laugeson, Elizabeth A. and Kennedy, Daniel P. and Adolphs, Ralph and Zhao, Qi (2015) Atypical Visual Saliency in Autism Spectrum Disorder Quantified through Model-Based Eye Tracking. Neuron, 88 (3). pp. 604-616. ISSN 0896-6273. PMCID PMC4662072. https://resolver.caltech.edu/CaltechAUTHORS:20151023-130102765

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Abstract

The social difficulties that are a hallmark of autism spectrum disorder (ASD) are thought to arise, at least in part, from atypical attention toward stimuli and their features. To investigate this hypothesis comprehensively, we characterized 700 complex natural scene images with a novel three-layered saliency model that incorporated pixel-level (e.g., contrast), object-level (e.g., shape), and semantic-level attributes (e.g., faces) on 5,551 annotated objects. Compared with matched controls, people with ASD had a stronger image center bias regardless of object distribution, reduced saliency for faces and for locations indicated by social gaze, and yet a general increase in pixel-level saliency at the expense of semantic-level saliency. These results were further corroborated by direct analysis of fixation characteristics and investigation of feature interactions. Our results for the first time quantify atypical visual attention in ASD across multiple levels and categories of objects.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://www.sciencedirect.com/science/article/pii/S0896627315008314PublisherArticle
http://dx.doi.org/10.1016/j.neuron.2015.09.042DOIArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4662072/PubMed CentralArticle
ORCID:
AuthorORCID
Kennedy, Daniel P.0000-0002-5915-0893
Adolphs, Ralph0000-0002-8053-9692
Additional Information:© 2015 Elsevier Inc. Received 25 April 2015, Revised 21 July 2015, Accepted 21 September 2015, Available online 22 October 2015. Published: October 22, 2015. We thank Elina Veytsman and Jessica Hopkins for help in recruiting research participants, Justin Lee and Tim Armstrong for collecting the data, Lynn Paul for psychological assessments, and Laurent Itti for valuable comments. This research was supported by a post-doctoral fellowship from the Autism Science Foundation (S.W.), a Fonds de Recherche du Québec en Nature et Technologies (FRQNT) predoctoral fellowship (X.M.D.), a NIH grant (K99MH094409/R00MH094409) and NARSAD Young Investigator Award (D.P.K.), the Caltech Conte Center for the Neurobiology of Social Decision Making from NIMH and a grant from Simons Foundation (SFARI Award 346839, R.A.), and the Singapore Defense Innovative Research Program 9014100596 and the Singapore Ministry of Education Academic Research Fund Tier 2 MOE2014-T2-1-144 (Q.Z.). Author Contributions: S.W., D.P.K., R.A., and Q.Z. designed experiments. S.W., M.J., and X.M.D. performed experiments. S.W., M.J., and Q.Z. analyzed data. E.A.L. helped with subject recruitment and assessment. S.W., R.A., and Q.Z. wrote the paper. All authors discussed the results and contributed toward the manuscript.
Funders:
Funding AgencyGrant Number
Autism Science FoundationUNSPECIFIED
Fonds de Recherche du Québec en Nature et Technologies (FRQNT)UNSPECIFIED
NIHK99MH094409
NIHR00MH094409
NARSAD Young Investigator AwardUNSPECIFIED
Caltech Conte Center for the Neurobiology of Social Decision MakingUNSPECIFIED
National Institutes of Mental Health (NIMH)UNSPECIFIED
Simons Foundation346839
Singapore Defense Innovative Research Program9014100596
Ministry of Education (Singapore)MOE2014-T2-1-144
Subject Keywords:autism spectrum disorder; saliency; eye tracking; semantics; center bias; faces; attention; social cognition
Issue or Number:3
PubMed Central ID:PMC4662072
Record Number:CaltechAUTHORS:20151023-130102765
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20151023-130102765
Official Citation:Shuo Wang, Ming Jiang, Xavier Morin Duchesne, Elizabeth A. Laugeson, Daniel P. Kennedy, Ralph Adolphs, Qi Zhao, Atypical Visual Saliency in Autism Spectrum Disorder Quantified through Model-Based Eye Tracking, Neuron, Volume 88, Issue 3, 4 November 2015, Pages 604-616, ISSN 0896-6273, http://dx.doi.org/10.1016/j.neuron.2015.09.042. (http://www.sciencedirect.com/science/article/pii/S0896627315008314)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:61499
Collection:CaltechAUTHORS
Deposited By: Joy Painter
Deposited On:23 Oct 2015 20:22
Last Modified:03 Oct 2019 09:08

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