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Developmental biologist Eric H. Davidson, 1937–2015

Hood, Leroy and Rothenberg, Ellen V. (2015) Developmental biologist Eric H. Davidson, 1937–2015. Proceedings of the National Academy of Sciences of the United States of America, 112 (44). pp. 13423-13425. ISSN 0027-8424. PMCID PMC4640791. doi:10.1073/pnas.1518876112. https://resolver.caltech.edu/CaltechAUTHORS:20151027-160800977

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Abstract

Eric H. Davidson, a world leader in developmental biology, demonstrated that most of development is, indeed, regulated by the genome. He was a pioneer researcher and theorist of the gene regulatory networks that execute the most complex biological processes, such as the cascade of molecular mechanisms that transform a single-celled egg into a complex creature. He insisted that the seemingly infinite details of classical developmental biology had to be explained in terms of the function of DNA sequences inherited in the genome, and showed how genomic information is used to initiate and drive forward development. His work emphasized a quantitative understanding of the biological mechanisms and the logic functions encoded in genetic networks, and focused on the question of how the genomic DNA could encode not only protein sequences but also the complex “software” needed for differentiating a myriad of cell types in the right places and proportions to make complex animals. He authored six books, ranging from his classic 1968 monograph, Gene Activity in Early Development, to his final book, Genomic Control Process: Development and Evolution (coauthored with Isabelle Peter), published this year.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1073/pnas.1518876112 DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640791/PubMed CentralArticle
ORCID:
AuthorORCID
Hood, Leroy0000-0001-7158-3678
Rothenberg, Ellen V.0000-0002-3901-347X
Additional Information:© 2015 National Academy of Sciences. Published ahead of print October 23, 2015. Author contributions: L.H. and E.V.R. wrote the paper. The authors declare no conflict of interest.
Issue or Number:44
PubMed Central ID:PMC4640791
DOI:10.1073/pnas.1518876112
Record Number:CaltechAUTHORS:20151027-160800977
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20151027-160800977
Official Citation:Leroy Hood and Ellen V. Rothenberg Developmental biologist Eric H. Davidson, 1937–2015 PNAS 2015 112 (44) 13423-13425; published ahead of print October 23, 2015, doi:10.1073/pnas.1518876112
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:61616
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:27 Oct 2015 23:18
Last Modified:10 Nov 2021 22:51

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