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Inactivation of Parietal Reach Region Affects Reaching But Not Saccade Choices in Internally Guided Decisions

Christopoulos, Vassilios N. and Bonaiuto, James and Kagan, Igor and Andersen, Richard A. (2015) Inactivation of Parietal Reach Region Affects Reaching But Not Saccade Choices in Internally Guided Decisions. Journal of Neuroscience, 35 (33). pp. 11719-11728. ISSN 0270-6474. PMCID PMC4540805. doi:10.1523/JNEUROSCI.1068-15.2015. https://resolver.caltech.edu/CaltechAUTHORS:20151029-153835707

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Abstract

The posterior parietal cortex (PPC) has traditionally been considered important for awareness, spatial perception, and attention. However, recent findings provide evidence that the PPC also encodes information important for making decisions. These findings have initiated a running argument of whether the PPC is critically involved in decision making. To examine this issue, we reversibly inactivated the parietal reach region (PRR), the area of the PPC that is specialized for reaching movements, while two monkeys performed a memory-guided reaching or saccade task. The task included choices between two equally rewarded targets presented simultaneously in opposite visual fields. Free-choice trials were interleaved with instructed trials, in which a single cue presented in the peripheral visual field defined the reach and saccade target unequivocally. We found that PRR inactivation led to a strong reduction of contralesional choices, but only for reaches. On the other hand, saccade choices were not affected by PRR inactivation. Importantly, reaching and saccade movements to single instructed targets remained largely intact. These results cannot be explained as an effector-nonspecific deficit in spatial attention or awareness, since the temporary “lesion” had an impact only on reach choices. Hence, the PPR is a part of a network for reach decisions and not just reach planning.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1523/JNEUROSCI.1068-15.2015DOIArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4540805/PubMed CentralArticle
ORCID:
AuthorORCID
Kagan, Igor0000-0002-1814-4200
Andersen, Richard A.0000-0002-7947-0472
Additional Information:© 2015 the authors. Beginning six months after publication the Work will be made freely available to the public on SfN’s website to copy, distribute, or display under a Creative Commons Attribution 4.0 International (CC BY 4.0) license (https://creativecommons.org/licenses/by/4.0/). Received March 18, 2015; revised June 5, 2015; accepted July 7, 2015. This work was supported by National Institutes of Health (R01 EY007492), Boswell Foundation, and Sloan-Swartz Foundation. We thank K. Pejsa for animal care, Dr. V. Shcherbatyuk for computer support, and Dr. M Hauschild and Dr. E Hwang for their valuable advice and support. Author contributions: V.N.C., J.B., I.K., and R.A.A. designed research; V.N.C. performed research; V.N.C. and J.B. contributed unpublished reagents/analytic tools; V.N.C. analyzed data; V.N.C., J.B., I.K., and R.A.A. wrote the paper.
Funders:
Funding AgencyGrant Number
NIHR01 EY007492
James G. Boswell FoundationUNSPECIFIED
Sloan-Swartz FoundationUNSPECIFIED
Issue or Number:33
PubMed Central ID:PMC4540805
DOI:10.1523/JNEUROSCI.1068-15.2015
Record Number:CaltechAUTHORS:20151029-153835707
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20151029-153835707
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:61720
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:29 Oct 2015 23:38
Last Modified:24 May 2022 22:33

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