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Gut biogeography of the bacterial microbiota

Donaldson, Gregory P. and Lee, S. Melanie and Mazmanian, Sarkis K. (2016) Gut biogeography of the bacterial microbiota. Nature Reviews Microbiology, 14 (1). pp. 20-32. ISSN 1740-1526. PMCID PMC4837114. http://resolver.caltech.edu/CaltechAUTHORS:20151102-104537010

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Abstract

Animals assemble and maintain a diverse but host-specific gut microbial community. In addition to characteristic microbial compositions along the longitudinal axis of the intestines, discrete bacterial communities form in microhabitats, such as the gut lumen, colonic mucus layers and colonic crypts. In this Review, we examine how the spatial distribution of symbiotic bacteria among physical niches in the gut affects the development and maintenance of a resilient microbial ecosystem. We consider novel hypotheses for how nutrient selection, immune activation and other mechanisms control the biogeography of bacteria in the gut, and we discuss the relevance of this spatial heterogeneity to health and disease.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1038/nrmicro3552DOIArticle
http://www.nature.com/nrmicro/journal/v14/n1/full/nrmicro3552.htmlPublisherArticle
http://rdcu.be/fGHrPublisherFree ReadCube access
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837114PubMed CentralArticle
ORCID:
AuthorORCID
Mazmanian, Sarkis K.0000-0003-2713-1513
Additional Information:© 2015 Macmillan Publishers Limited. Published online 26 October 2015. The authors thank E. Hsiao, B. Needham and T. Sampson for critical comments on the manuscript. G.P.D. is supported by a US National Science Foundation Graduate Research Fellowship (grant DGE‑1144469). Work in the S.K.M. laboratory is supported by funding from the US National Institutes of Health (grants GM099535, DK078938 and MH100556), the Emerald Foundation and the Simons Foundation. The authors declare no competing interests.
Funders:
Funding AgencyGrant Number
NSF Graduate Research FellowshipDGE-1144469
NIHGM099535
NIHDK078938
NIHMH100556
Emerald FoundationUNSPECIFIED
Simons FoundationUNSPECIFIED
PubMed Central ID:PMC4837114
Record Number:CaltechAUTHORS:20151102-104537010
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20151102-104537010
Official Citation:Gut biogeography of the bacterial microbiota Gregory P. Donaldson, S. Melanie Lee & Sarkis K. Mazmanian Nature Reviews Microbiology 14, 20–32 (2016) doi:10.1038/nrmicro3552
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:61768
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:02 Nov 2015 20:51
Last Modified:18 Jul 2017 21:33

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