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Natural supramolecular protein assemblies

Pieters, Bas J. G. E. and van Eldijk, Mark B. and Nolte, Roeland J. M. and Mecinović, Jasmin (2016) Natural supramolecular protein assemblies. Chemical Society Reviews, 45 (1). pp. 24-39. ISSN 0306-0012.

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Supramolecular protein assemblies are an emerging area within the chemical sciences, which combine the topological structures of the field of supramolecular chemistry and the state-of-the-art chemical biology approaches to unravel the formation and function of protein assemblies. Recent chemical and biological studies on natural multimeric protein structures, including fibers, rings, tubes, catenanes, knots, and cages, have shown that the quaternary structures of proteins are a prerequisite for their highly specific biological functions. In this review, we illustrate that a striking structural diversity of protein assemblies is present in nature. Furthermore, we describe structure–function relationship studies for selected classes of protein architectures, and we highlight the techniques that enable the characterisation of supramolecular protein structures.

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Additional Information:© 2015 The Royal Society of Chemistry. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Received 18 Feb 2015, First published online 26 Oct 2015. We thank the Netherlands Research School for Chemical Biology (NRSCB, J. M.), the European Research Council (ERC Advanced Grant, ALPROS-290886, R. J. M. N.) and the Netherlands Organisation for Scientific Research (Rubicon fellowship, M. B. v. E.) for financial support.
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Netherlands Research School for Chemical Biology (NRSCB)UNSPECIFIED
European Research Council (ERC)ALPROS-290886
Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO)UNSPECIFIED
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Record Number:CaltechAUTHORS:20151103-075107447
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Official Citation:Natural supramolecular protein assemblies Bas J. G. E. Pieters, Mark B. van Eldijk, Roeland J. M. Noltea and Jasmin Mecinović Chem. Soc. Rev., 2016, 45, 24-39 DOI: 10.1039/C5CS00157A
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:61779
Deposited By: Tony Diaz
Deposited On:03 Nov 2015 19:47
Last Modified:03 Oct 2019 09:11

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