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Immunoglobulin Structure: Amino Terminal Sequences of Mouse Myeloma Proteins That Bind Phosphorylcholine

Barstad, P. and Rudikoff, S. and Potter, M. and Cohn, M. and Konigsberg, W. and Hood, L. (1974) Immunoglobulin Structure: Amino Terminal Sequences of Mouse Myeloma Proteins That Bind Phosphorylcholine. Science, 183 (4128). pp. 962-964. ISSN 0036-8075. https://resolver.caltech.edu/CaltechAUTHORS:20151112-121121305

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Abstract

The amino terminal sequences of five light and heavy immunoglobulin chains from myeloma proteins of the BALB/c mouse with binding activity to phosphorylcholine are presented. Except for a single substitution in position 4, all five heavy chains have identical amino terminal sequences through the first hypervariable region. Proteins which share unique (idiotypic) antigenic determinants are identical through the first hypervariable region of their light and heavy chains. Proteins with differing idiotypic determinants have light chains of differing amino acid sequence. These observations suggest that the heavy chain plays a more important role than the light chain in determining the phosphorylcholine binding site.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1126/science.183.4128.962 DOIArticle
http://www.sciencemag.org/content/183/4128/962.abstractPublisherArticle
http://www.jstor.org/stable/1737908JSTORArticle
ORCID:
AuthorORCID
Hood, L.0000-0001-7158-3678
Additional Information:© 1974 American Association for the Advancement of Science. 16 November 1973.
Issue or Number:4128
Record Number:CaltechAUTHORS:20151112-121121305
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20151112-121121305
Official Citation:Immunoglobulin Structure: Amino Terminal Sequences of Mouse Myeloma Proteins That Bind Phosphorylcholine P. Barstad, S. Rudikoff, M. Potter, M. Cohn, W. Konigsberg, and L. Hood Science 8 March 1974: 183 (4128), 962-964. [DOI:10.1126/science.183.4128.962]
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:62072
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:13 Nov 2015 22:23
Last Modified:03 Mar 2020 13:01

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