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Localization of the Globin Gene in the Template Active Fraction of Chromatin of Friend Leukemia Cells

Wallace, R. Bruce and Dube, Shyam K. and Bonner, James (1977) Localization of the Globin Gene in the Template Active Fraction of Chromatin of Friend Leukemia Cells. Science, 198 (4322). pp. 1166-1168. ISSN 0036-8075. doi:10.1126/science.270812.

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Friend leukemia cell chromatin has been fractionated into template active and inactive components. The globin gene sequence is associated with the template active component both prior to and after the cells are induced with dimethyl sulfoxide to synthesize hemoglobin and therefore appears to be in an active configuration in uninduced as well as in induced Friend leukemia cells. In cells which have lost the ability to produce hemoglobin, the globin gene sequence is not associated with the template active fraction of chromatin. These results demonstrate the success of the fractionation procedure.

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Additional Information:© 1977 American Association for the Advancement of Science. 10 March 1977; revised 29 July 1977. We thank I. B. Pragnell and W. Ostertag for a gift of globin cDNA and helpful discussions. This research was supported by PHS grant GM-13762. S.K.D. has been supported as a Sherman Fairchild Distinguished Scholar at the California Institute of Technology. R.B.W. is the recipient of a Medical Research Council of Canada fellowship.
Funding AgencyGrant Number
Public Health ServiceGM-13762
Medical Research Council of CanadaUNSPECIFIED
Issue or Number:4322
Record Number:CaltechAUTHORS:20151117-080411815
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Official Citation:Localization of the globin gene in the template active fraction of chromatin of Friend leukemia cells RB Wallace, SK Dube, and J Bonner Science 16 December 1977: 198 (4322), 1166-1168. [DOI:10.1126/science.270812]
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:62149
Deposited By: Ruth Sustaita
Deposited On:17 Nov 2015 16:43
Last Modified:10 Nov 2021 22:58

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