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An Odorant Derivative as an Antagonist for an Olfactory Receptor

Oka, Yuki and Nakamura, Akio and Watanabe, Hidenori and Touhara, Kazushige (2004) An Odorant Derivative as an Antagonist for an Olfactory Receptor. Chemical Senses, 29 (9). pp. 815-822. ISSN 0379-864X. doi:10.1093/chemse/bjh247.

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Different odorants are recognized by different combinations of G protein-coupled olfactory receptors, and thereby, odor identity is determined by a combinatorial receptor code for each odorant. We recently demonstrated that odorants appeared to compete for receptor sites to act as an agonist or an antagonist. Therefore, in natural circumstances where we always perceive a mixture of various odorants, olfactory receptor antagonism between odorants may result in a receptor code for the mixture that cannot be predicted from the codes for its individual components. Here we show that stored isoeugenol has an antagonistic effect on a mouse olfactory receptor, mOR-EG. However, freshly purified isoeugenol did not have an inhibitory effect. Instead, an isoeugenol derivative produced during storage turned out to be a potent competitive antagonist of mOR-EG. Structural analysis revealed that this derivative is an oxidatively dimerized isoeugenol that naturally occurs by oxidative reaction. The current study indicates that as odorants age, they decompose or react with other odorants, which in turn affects responsiveness of an olfactory receptor(s).

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Additional Information:© 2004 Oxford University Press. Accepted September 27, 2004. We thank T. Wada, T. Kawanaka and their colleagues for helping with NMR analysis and technical advice and H. Kataoka for support. Special thanks are due to people in T. Hasegawa Co., Ltd for helpful discussion. This work was supported in part by grants from the Japan Society for the Promotion of Science (JSPS) and the Program for Promotion of Basic Research Activities for Innovative Biosciences (PROBRAIN) Japan. K.T. is recipient of grants from Uehara Memorial Foundation, Kato Memorial Bioscience Foundation, The Naito Foundation and The Mochida Memorial Foundation.
Funding AgencyGrant Number
Japan Society for the Promotion of Science (JSPS)UNSPECIFIED
Uehara Memorial FoundationUNSPECIFIED
Kato Memorial Bioscience FoundationUNSPECIFIED
Naito FoundationUNSPECIFIED
Mochida Memorial FoundationUNSPECIFIED
Subject Keywords:antagonist; isoeugenol; odorant; olfactory receptor
Issue or Number:9
Record Number:CaltechAUTHORS:20151118-134439519
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Official Citation:Yuki Oka, Akio Nakamura, Hidenori Watanabe, and Kazushige Touhara An Odorant Derivative as an Antagonist for an Olfactory Receptor Chem. Senses (2004) 29 (9): 815-822 doi:10.1093/chemse/bjh247
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:62211
Deposited By: George Porter
Deposited On:18 Nov 2015 23:37
Last Modified:10 Nov 2021 22:59

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