CaltechAUTHORS
  A Caltech Library Service

Hand Shape Representations in the Human Posterior Parietal Cortex

Klaes, Christian and Kellis, Spencer and Aflalo, Tyson and Lee, Brian and Pejsa, Kelsie and Shanfield, Kathleen and Hayes-Jackson, Stephanie and Aisen, Mindy and Heck, Christi and Liu, Charles and Andersen, Richard A. (2015) Hand Shape Representations in the Human Posterior Parietal Cortex. Journal of Neuroscience, 35 (46). pp. 15466-15476. ISSN 0270-6474. PMCID PMC4649012. http://resolver.caltech.edu/CaltechAUTHORS:20151120-091934442

[img] PDF - Published Version
Creative Commons Attribution.

2883Kb

Use this Persistent URL to link to this item: http://resolver.caltech.edu/CaltechAUTHORS:20151120-091934442

Abstract

Humans shape their hands to grasp, manipulate objects, and to communicate. From nonhuman primate studies, we know that visual and motor properties for grasps can be derived from cells in the posterior parietal cortex (PPC). Are non-grasp-related hand shapes in humans represented similarly? Here we show for the first time how single neurons in the PPC of humans are selective for particular imagined hand shapes independent of graspable objects. We find that motor imagery to shape the hand can be successfully decoded from the PPC by implementing a version of the popular Rock-Paper-Scissors game and its extension Rock-Paper-Scissors-Lizard-Spock. By simultaneous presentation of visual and auditory cues, we can discriminate motor imagery from visual information and show differences in auditory and visual information processing in the PPC. These results also demonstrate that neural signals from human PPC can be used to drive a dexterous cortical neuroprosthesis.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1523/JNEUROSCI.2747-15.2015DOIArticle
http://www.jneurosci.org/content/35/46/15466.abstractPublisherArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649012/PubMed CentralArticle
ORCID:
AuthorORCID
Klaes, Christian0000-0003-4767-9631
Additional Information:© 2015 the authors. Beginning six months after publication the Work will be made freely available to the public on SfN’s website to copy, distribute, or display under a Creative Commons Attribution 4.0 International (CC BY 4.0) license (https://creativecommons.org/licenses/by/4.0/). Received July 20, 2015. Revision received September 22, 2015. Accepted October 16, 2015. This work was supported by the NIH (grants EY013337, EY015545, and P50 MH942581A), the Boswell Foundation, the USC Neurorestauration Center, and DoD contract N66001-10-C-4056. We thank Viktor Shcherbatyuk for computer assistance, Tessa Yao, Alicia Berumen, and Sandra Oviedo for administrative support; Kirsten Durkin for nursing assistance; and our colleagues from the Applied Physics Laboratory at John Hopkins University for technical support with the robotic limb. Author contributions: C.K. and R.A.A. designed research; C.K., S.K., T.A., B.L., K.P., K.S., S.H.-J., M.A., C.H., and C.L. performed research; C.K. analyzed data; C.K. and R.A.A. wrote the paper. The authors declare no competing financial interests.
Funders:
Funding AgencyGrant Number
NIHEY013337
NIHEY015545
NIHP50 MH942581A
Boswell FoundationUNSPECIFIED
USC Neurorestoration CenterUNSPECIFIED
Office of Naval Research (ONR)N66001-10-C-4056
Subject Keywords:audio processing; brain–machine interface; grasping; hand shaping; motor imagery; posterior parietal cortex
PubMed Central ID:PMC4649012
Record Number:CaltechAUTHORS:20151120-091934442
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20151120-091934442
Official Citation:Hand Shape Representations in the Human Posterior Parietal Cortex Christian Klaes, Spencer Kellis, Tyson Aflalo, Brian Lee, Kelsie Pejsa, Kathleen Shanfield, Stephanie Hayes-Jackson, Mindy Aisen, Christi Heck, Charles Liu, and Richard A. Andersen The Journal of Neuroscience, 18 November 2015, 35(46):15466-15476; doi:10.1523/JNEUROSCI.2747-15.2015
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:62278
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:20 Nov 2015 17:32
Last Modified:28 Feb 2018 19:51

Repository Staff Only: item control page