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Induction of Mutations in a Bacterial Virus

Weigle, J. J. (1953) Induction of Mutations in a Bacterial Virus. Proceedings of the National Academy of Sciences of the United States of America, 39 (7). pp. 628-636. ISSN 0027-8424.

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In the course of experiments designed for other purposes a paradoxical observation was made: phage λ, inactivated by UV irradiation, when adsorbed onto sensitive bacteria was reactivated when a further dose of UV was given to the phage-bacterium complexes. Among the reactivated phages a fairly large proportion were mutants. A description of these findings and a discussion of their implications will be found below.

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Additional Information:Copyright © 1953 by the National Academy of Sciences Communicated by M. Delbrück, May 12, 1953 The author gratefully acknowledges the constant help and advice he received in the course of this investigation from Dr. M. Delbrück, Dr. R. Dulbecco, and Dr. M. Vogt. He is also indebted to Dr. R. Appleyard, Dr. M. Lieb, and Mr. D. Kaiser for the bacterial strains used and for communications of unpublished results. This investigation was supported by a grant from the National Foundation for Infantile Paralysis.
Issue or Number:7
Record Number:CaltechAUTHORS:WEIpnas53
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:6236
Deposited By: Archive Administrator
Deposited On:29 Nov 2006
Last Modified:02 Oct 2019 23:30

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