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Optical focusing inside scattering media with time-reversed ultrasound microbubble encoded light

Ruan, Haowen and Jang, Mooseok and Yang, Changhuei (2015) Optical focusing inside scattering media with time-reversed ultrasound microbubble encoded light. Nature Communications, 6 . Art. No. 8968. ISSN 2041-1723. PMCID PMC4673873. http://resolver.caltech.edu/CaltechAUTHORS:20151124-095652864

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Abstract

Focusing light inside scattering media in a freely addressable fashion is challenging, as the wavefront of the scattered light is highly disordered. Recently developed ultrasound-guided wavefront shaping methods are addressing this challenge, albeit with relatively low modulation efficiency and resolution limitations. In this paper, we present a new technique, time-reversed ultrasound microbubble encoded (TRUME) optical focusing, which can focus light with improved efficiency and sub-ultrasound wavelength resolution. This method ultrasonically destroys microbubbles, and measures the wavefront change to compute and render a suitable time-reversed wavefront solution for focusing. We demonstrate that the TRUME technique can create an optical focus at the site of bubble destruction with a size of ~2 μm. We further demonstrate a twofold enhancement in addressable focus resolution in a microbubble aggregate target by exploiting the nonlinear pressure-to-destruction response of the microbubbles. The reported technique provides a deep tissue-focusing solution with high efficiency, resolution, and specificity.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://arxiv.org/abs/1506.05190arXivDiscussion Paper
http://dx.doi.org/10.1038/ncomms9968DOIArticle
http://www.nature.com/ncomms/2015/151124/ncomms9968/full/ncomms9968.htmlPublisherArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673873/PubMed CentralArticle
Alternate Title:Optical focusing inside scattering media with time-reversed ultrasound microbubble encoded (TRUME) light
Additional Information:© 2015 Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. Received 24 July 2015; Accepted 22 October 2015; Published 24 November 2015. We thank Dr Daifa Wang for developing the idea, Mr Roarke Horstmeyer for the comments on the mathematics and the manuscript, and Mr Joshua Brake as well as Mr Edward Zhou for helpful discussions. We also like to thank Dr Mikhail G. Shapiro, Dr Stephen P. Morgan and Dr Melissa L. Mather for the discussions on microbubbles. This work is supported by the National Institutes of Health (1DP2OD007307-01), the National Institutes of Health BRAIN Initiative (1U01NS090577-01) and the GIST-Caltech Collaborative Research Proposal (CG2012). Author contributions: H.R. and M.J. contributed equally to the work. H.R. conceived the idea. H.R., M.J. and C.Y. developed the idea and designed the experiments, which were carried out by H.R. and M.J. Data analysis was carried out by H.R. and M.J. with help from C.Y. who also supervised the project. All authors contributed to the preparation of the manuscript.
Funders:
Funding AgencyGrant Number
NIH1DP2OD007307-01
NIH1U01NS090577-01
GIST-CaltechCG2012
PubMed Central ID:PMC4673873
Record Number:CaltechAUTHORS:20151124-095652864
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20151124-095652864
Official Citation:Ruan, H. et al. Optical focusing inside scattering media with time-reversed ultrasound microbubble encoded light. Nat. Commun. 6:8968 doi: 10.1038/ncomms9968 (2015)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:62360
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:24 Nov 2015 18:08
Last Modified:13 Mar 2017 19:19

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