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Coordinated Spatial Pattern Formation in Biomolecular Communication Networks

Hori, Yutaka and Miyazako, Hiroki and Kumagai, Soichiro and Hara, Shinji (2015) Coordinated Spatial Pattern Formation in Biomolecular Communication Networks. IEEE Transactions on Molecular, Biological and Multi-Scale Communications, 1 (2). pp. 111-121. ISSN 2332-7804. https://resolver.caltech.edu/CaltechAUTHORS:20151124-113609021

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Abstract

This paper proposes a control theoretic framework to model and analyze the self-organized pattern formation of molecular concentrations in biomolecular communication networks, emerging applications in synthetic biology. In biomolecular communication networks, bio-nanomachines, or biological cells, communicate with each other using a cell-to-cell communication mechanism mediated by a diffusible signaling molecule, thereby the dynamics of molecular concentrations are approximately modeled as a reaction-diffusion system with a single diffuser. We first introduce a feedback model representation of the reaction-diffusion system and provide a systematic local stability/instability analysis tool using the root locus of the feedback system. The instability analysis then allows us to analytically derive the conditions for the self-organized spatial pattern formation, or Turing pattern formation, of the bionanomachines. We propose a novel synthetic biocircuit motif called activator-repressor-diffuser system and show that it is one of the minimum biomolecular circuits that admit self-organized patterns over cell population.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1109/TMBMC.2015.2500567DOIArticle
http://ieeexplore.ieee.org/xpl/articleDetails.jsp?arnumber=7328285PublisherArticle
http://arxiv.org/abs/1504.06045arXivDiscussion Paper
Additional Information:© 2015 IEEE. Y. Hori was supported by JSPS Fellowship for Research Abroad. This work was supported, in part, by Grant-in-Aid for Scientific Research (A) of the Ministry of Education, Culture, Sports, Science, and Technology, Japan, No. 21246067, and Grant-in-Aid for JSPS Fellows under grant number 15J09841.
Funders:
Funding AgencyGrant Number
Japan Society for the Promotion of Science (JSPS)15J09841
Ministry of Education, Culture, Sports, Science and Technology (MEXT)21246067
Subject Keywords:Molecular communication networks, Self-organization, Stability analysis, Turing pattern
Issue or Number:2
Record Number:CaltechAUTHORS:20151124-113609021
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20151124-113609021
Official Citation:Hori, Y.; Miyazako, H.; Kumagai, S.; Hara, S., "Coordinated Spatial Pattern Formation in Biomolecular Communication Networks," in Molecular, Biological and Multi-Scale Communications, IEEE Transactions on , vol.1, no.2, pp.111-121, June 2015 doi: 10.1109/TMBMC.2015.2500567
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:62376
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:24 Nov 2015 21:05
Last Modified:03 Oct 2019 09:18

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