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A Monoclonal Antibody Specific to a Song System Nuclear Antigen in Estrildine Finches

Akutagawa, Eugene and Konishi, Masakazu (2001) A Monoclonal Antibody Specific to a Song System Nuclear Antigen in Estrildine Finches. Neuron, 31 (4). pp. 545-556. ISSN 0896-6273. https://resolver.caltech.edu/CaltechAUTHORS:20151124-145659874

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Abstract

This paper describes a monoclonal antibody that recognizes a molecule whose expression is mostly restricted to some of the forebrain areas that control singing behavior in adult estrildine species studied, including the zebra, Bengalese, and spice finches. When the song system displays extreme sexual dimorphism, as in these species, antibody staining occurs only in the male's song nuclei. However, protein expression is identical in both sexes of estrildine finches, in which females also have a well-developed song system. Canaries appear to lack the protein, but it can be induced in female zebra finches by early estrogen treatment. Antibody staining patterns in the zebra finch show that the protein's expression is developmentally regulated to coincide with the abrupt increase in the volume and cell size of the male's or the estrogen-treated female's song system.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/S0896-6273(01)00388-9DOIArticle
http://www.sciencedirect.com/science/article/pii/S0896627301003889PublisherArticle
Additional Information:© 2001 Elsevier. Received 25 January 2001, Revised 14 June 2001, Available online 7 September 2001. We thank the Monoclonal Facilities at Caltech for producing the antibody, Miriam Zucker for helping with the initial screening of the antibody, and Paul Patterson and Allison Doupe for the critical reading of the manuscript.
Issue or Number:4
Record Number:CaltechAUTHORS:20151124-145659874
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20151124-145659874
Official Citation:Eugene Akutagawa, Masakazu Konishi, A Monoclonal Antibody Specific to a Song System Nuclear Antigen in Estrildine Finches, Neuron, Volume 31, Issue 4, 30 August 2001, Pages 545-556, ISSN 0896-6273, http://dx.doi.org/10.1016/S0896-6273(01)00388-9. (http://www.sciencedirect.com/science/article/pii/S0896627301003889)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:62397
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:25 Nov 2015 18:15
Last Modified:03 Oct 2019 09:18

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