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Distribution of GABAergic neurons and terminals in the auditory system of the barn owl

Carr, C. E. and Fujita, I. and Konishi, M. (1989) Distribution of GABAergic neurons and terminals in the auditory system of the barn owl. Journal of Comparative Neurology, 286 (2). pp. 190-207. ISSN 0021-9967. doi:10.1002/cne.902860205.

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Antisera to GAD (glutamic acid decarboxylase) and GABA were used to determine the distribution of GABAergic cells and terminals in the brainstem and midbrain auditory nuclei of the barn owl. The owl processes time and intensity components of the auditory signal in separate pathways, and each pathway has a distinctive pattern of GAD- and GABA-like immunoreactivity. In the time pathway, all the cells of the cochlear nucleus magnocellularis and nucleus laminaris receive perisomatic GABAergic terminals, and small numbers of GABAergic neurons surround both nuclei. The ventral nucleus of the lateral lemniscus (anterior division) contains both immunoreactive terminals and some GABAergic neurons. In the intensity pathway, dense immunoreactive terminals are distributed throughout the cochlear nucleus angularis, which also contains a small number of GABAergic neurons. The superior olive contains two GABAergic cell types and immunoreactive terminals distributed throughout the neuropil. All the neurons of the nucleus of the lateral lemniscus (ventral part) appear to be GABAergic, and this nucleus also contains a moderate number of immunoreactive terminals. Immunoreactive terminals are distributed throughout the neuropil of the ventral nucleus of the lateral lemniscus (posterior division), whereas multipolar and small fusiform GABAergic neurons predominate in the dorsal regions of the nucleus. The time and intensity pathways combine in the inferior colliculus. The central nucleus of the inferior colliculus contains a large number of fusiform and stellate GABAergic neurons and a dense plexus of immunoreactive terminals, whereas the external nucleus contains slightly fewer immunoreactive cells and terminals. The superficial nucleus contains dense, fine immunoreactive terminals and a small number of GABAergic neurons.

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Additional Information:© 1989 Alan R. Liss, Inc. Accepted March 16, 1989. We are most grateful to Dr. Nicholas Brecha for his assistance and the use of his facilities during this project. We thank Drs. W. Oertel and I. Kopin for generously providing the antiserum to GAD and Dr. R.J. Wenthold for providing the antiserum to GABA. Dr. Terry Takahashi assisted with some of the GABA immunohistocbemislry and Dr. Harvey Karten gave valuable technical advice. We thank Drs. Becky Code, Terry Takahashi, Susan Volman, Chris von Bartheld, and Hermann Wagner for their helpful criticisms of this manuscript. Supported by NRSA NS07475 to C.E.C., by a grant from the Uehara Memorial foundation to I.F., and by grant NSI 14617 to M.K.
Funding AgencyGrant Number
National Research Service Award (NRSA)NS07475
Uehara Memorial FoundationUNSPECIFIED
National Institute of Neurological Disorders and Stroke (NINDS)NSI 14617
Subject Keywords:GAD;immunohistochemistry;inferior colliculus;lemniscal nuclei;cochlear nuclei
Issue or Number:2
Record Number:CaltechAUTHORS:20151125-102722061
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Official Citation:Carr, C. E., Fujita, I. and Konishi, M. (1989), Distribution of GABAergic neurons and terminals in the auditory system of the barn owl. J. Comp. Neurol., 286: 190–207. doi: 10.1002/cne.902860205
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:62422
Deposited By: Ruth Sustaita
Deposited On:25 Nov 2015 18:58
Last Modified:10 Nov 2021 23:02

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