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Emergence of Multiplicative Auditory Responses in the Midbrain of the Barn Owl

Fischer, Brian J. and Peña, José Luis and Konishi, Masakazu (2007) Emergence of Multiplicative Auditory Responses in the Midbrain of the Barn Owl. Journal of Neurophysiology, 98 (3). pp. 1181-1193. ISSN 0022-3077. PMCID PMC2532518. https://resolver.caltech.edu/CaltechAUTHORS:20151201-111850361

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Abstract

Space-specific neurons in the barn owl's auditory space map gain spatial selectivity through tuning to combinations of the interaural time difference (ITD) and interaural level difference (ILD). The combination of ITD and ILD in the subthreshold responses of space-specific neurons in the external nucleus of the inferior colliculus (ICx) is well described by a multiplication of ITD- and ILD-dependent components. It is unknown, however, how ITD and ILD are combined at the site of ITD and ILD convergence in the lateral shell of the central nucleus of the inferior colliculus (ICcl) and therefore whether ICx is the first site in the auditory pathway where multiplicative tuning to ITD- and ILD-dependent signals occurs. We used extracellular recording of single neurons to determine how ITD and ILD are combined in ICcl of the anesthetized barn owl (Tyto alba). A comparison of additive, multiplicative, and linear-threshold models of neural responses shows that ITD and ILD are combined nonlinearly in ICcl, but the interaction of ITD and ILD is not uniformly multiplicative over the sample. A subset (61%) of the neural responses is well described by the multiplicative model, indicating that ICcl is the first site where multiplicative tuning to ITD- and ILD-dependent signals occurs. ICx, however, is the first site where multiplicative tuning is observed consistently. A network model shows that a linear combination of ICcl responses to ITD–ILD pairs is sufficient to produce the multiplicative subthreshold responses to ITD and ILD seen in ICx.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1152/jn.00370.2007 DOIArticle
http://jn.physiology.org/content/98/3/1181.longPublisherArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2532518PubMed CentralArticle
Additional Information:© 2007 The American Physiological Society. Submitted 1 April 2007; accepted in final form 2 July 2007. We thank K. Mori and R. Wessel for providing comments on earlier versions of the manuscript, B. Christianson for discussions about data analysis, and G. Akutagawa for histology. This work was supported by National Institute on Deafness and Other Communication Disorders Grants DC-00134 to M. Konishi and DC-007690 to J. L. Peña.
Funders:
Funding AgencyGrant Number
National Institute of Deafness and Other Communication DisordersDC-00134
National Institute of Deafness and Other Communication DisordersDC-007690
Issue or Number:3
PubMed Central ID:PMC2532518
Record Number:CaltechAUTHORS:20151201-111850361
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20151201-111850361
Official Citation:Emergence of Multiplicative Auditory Responses in the Midbrain of the Barn Owl Brian J. Fischer, José Luis Peña, Masakazu Konishi Journal of Neurophysiology Published 1 September 2007 Vol. 98 no. 3, 1181-1193 DOI: 10.1152/jn.00370.2007
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:62499
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:02 Dec 2015 21:21
Last Modified:03 Oct 2019 09:19

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