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Passive Soma Facilitates Submillisecond Coincidence Detection in the Owl's Auditory System

Ashida, Go and Abe, Kousuke and Funabiki, Kazuo and Konishi, Masakazu (2007) Passive Soma Facilitates Submillisecond Coincidence Detection in the Owl's Auditory System. Journal of Neurophysiology, 97 (3). pp. 2267-2282. ISSN 0022-3077. https://resolver.caltech.edu/CaltechAUTHORS:20151201-111850646

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Abstract

Neurons of the avian nucleus laminaris (NL) compute the interaural time difference (ITD) by detecting coincident arrivals of binaural signals with submillisecond accuracy. The cellular mechanisms for this temporal precision have long been studied theoretically and experimentally. The myelinated axon initial segment in the owl's NL neuron and small somatic spikes observed in auditory coincidence detector neurons of various animals suggest that spikes in the NL neuron are generated at the first node of Ranvier and that the soma passively receives back-propagating spikes. To investigate the significance of the “passive soma” structure, we constructed a two-compartment NL neuron model, consisting of a cell body and a first node, and systematically changed the excitability of each compartment. Here, we show that a neuron with a less active soma achieves higher ITD sensitivity and higher noise tolerance with lower energy costs. We also investigate the biophysical mechanism of the computational advantage of the “passive soma” structure by performing sub- and suprathreshold analyses. Setting a spike initiation site with high sodium conductance, not in the large soma but in the small node, serves to amplify high-frequency input signals and to reduce the impact and the energy cost of spike generation. Our results indicate that the owl's NL neuron uses a “passive soma” design for computational and metabolic reasons.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1152/jn.00399.2006DOIArticle
http://jn.physiology.org/content/97/3/2267PublisherArticle
Additional Information:© 2007 The American Physiological Society. Submitted 16 April 2006; accepted in final form 27 November 2006. The authors thank L. Moore for telling us of the importance of the impedance analysis of a neuron. We also thank S. Seung and H. Kuba for critical reading of the early version of the manuscript and A. Reyes and two anonymous reviewers for careful reading of this manuscript and providing useful comments. G. Ashida is grateful to Y. Nakayama for help in preparing the manuscript. This work was supported by a fellowship for young scientists to study abroad from Japan Society for the Promotion of Science and the special coordinated funds from Ministry of Education, Culture, Sports, Science and Technology to K. Funabiki.
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Japan Society for the Promotion of Science (JSPS)UNSPECIFIED
Ministry of Education, Culture, Sports, Science and Technology (MEXT)UNSPECIFIED
Issue or Number:3
Record Number:CaltechAUTHORS:20151201-111850646
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20151201-111850646
Official Citation:Passive Soma Facilitates Submillisecond Coincidence Detection in the Owl's Auditory System Go Ashida, Kousuke Abe, Kazuo Funabiki, Masakazu Konishi Journal of Neurophysiology Published 1 March 2007 Vol. 97 no. 3, 2267-2282 DOI: 10.1152/jn.00399.2006
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:62500
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:02 Dec 2015 21:38
Last Modified:03 Oct 2019 09:19

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