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From Postsynaptic Potentials to Spikes in the Genesis of Auditory Spatial Receptive Fields

Peña, José Luis and Konishi, Masakazu (2002) From Postsynaptic Potentials to Spikes in the Genesis of Auditory Spatial Receptive Fields. Journal of Neuroscience, 22 (13). pp. 5652-5658. ISSN 0270-6474. PMCID PMC6758218. doi:10.1523/jneurosci.22-13-05652.2002.

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Space-specific neurons in the owl's inferior colliculus respond only to a sound coming from a particular direction, which is equivalent to a specific combination of interaural time difference (ITD) and interaural level difference (ILD). Comparison of subthreshold postsynaptic potentials (PSPs) and spike output for the same neurons showed that receptive fields measured in PSPs were much larger than those measured in spikes in both ITD and ILD dimensions. Space-specific neurons fire more spikes for a particular ITD than for its phase equivalents (ITD +/- 1/F, where F is best frequency). This differential response was much less pronounced in PSPs. The two sides of pyramid-shaped ILD curves were more symmetrical in spikes than in PSPs. Furthermore, monaural stimuli that were ineffective in eliciting spikes induced subthreshold PSPs. The main cause of these changes between PSPs and spikes is thresholding. The spiking threshold did not vary with the kind of acoustic stimuli presented. However, the thresholds of sound-induced first spikes were lower than those of later sound-induced and spontaneous spikes. This change in threshold may account for the sharpening of ITD selectivity during the stimulus. Large changes in receptive fields across single neurons are not unique to the owl's space-specific neurons but occur in mammalian visual and somatosensory cortices, suggesting the existence of general principles in the formation of receptive fields in high-order neurons.

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Additional Information:© 2002 Society for Neuroscience. For the first six months after publication SfN’s license will be exclusive. Beginning six months after publication the Work will be made freely available to the public on SfN’s website to copy, distribute, or display under a Creative Commons Attribution 4.0 International (CC BY 4.0) license ( Received Feb. 25, 2002; revised April 12, 2002; accepted April 22, 2002. This work was supported by National Institute of Neurological Disorders and Stroke Grant DC-00134. We thank Ben Arthur for providing us with the extracellular data in the ICx; Ben Arthur, Kazuo Funabiki, Yoram Gutfreund, Eric Knudsen, Lee Moore, Teresa Nick, and Terry Takahashi for reviewing early drafts of this manuscript; and Chris Malek, Ben Arthur, and Bjorn Christianson for help with computer programming.
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Subject Keywords:receptive fields; maps of space; sound localization; auditory system; barn owl; inferior colliculus
Issue or Number:13
PubMed Central ID:PMC6758218
Record Number:CaltechAUTHORS:20151202-073342132
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Official Citation:From Postsynaptic Potentials to Spikes in the Genesis of Auditory Spatial Receptive Fields José Luis Peña and Masakazu Konishi The Journal of Neuroscience, 1 July 2002, 22(13):5652-5658
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:62523
Deposited By: Ruth Sustaita
Deposited On:02 Dec 2015 21:44
Last Modified:10 Nov 2021 23:03

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