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Calcium Binding Protein-Like Immunoreactivity Labels the Terminal Field of Nucleus Laminaris of the Barn Owl

Takahashi, Terry T. and Carr, Catherine E. and Brecha, Nicholas and Konishi, Masakazu (1987) Calcium Binding Protein-Like Immunoreactivity Labels the Terminal Field of Nucleus Laminaris of the Barn Owl. Journal of Neuroscience, 7 (6). pp. 1843-1856. ISSN 0270-6474. PMCID PMC6568887. doi:10.1523/jneurosci.07-06-01843.1987.

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Nucleus laminaris (NL) is the site at which the timing of sounds arriving in the 2 ears is compared in the auditory system of the barn owl. Earlier studies have reported vitamin D-dependent calcium binding protein (CaBP)-like immunoreactivity in the somata of NL. We report here that CaBP-like immunoreactivity stains the terminal field of NL. The specific CaBP immunoreactivity is localized to a dense plexus of fibers that have bouton-like swellings, usually around unstained somata. This type of immunoreactivity is found in a restricted portion of the central nucleus of the inferior colliculus (ICc), in the anterior division of the ventral lateral lemniscal complex (VLVA), and in the superior olivary nucleus (SO), all of which have been shown by anterograde transport of 3H-proline to be innervated by NL. The immunoreactivity is absent from the posterior division of ventral lateral lemniscal complex and from the region that surrounds the portion of ICc innervated by NL. A restricted lesion in NL results in a localized deficit in immunoreactivity in those regions of ICc and VLVA that are known to be innervated by the lesioned area of NL. In adjacent sections processed by the Fink-Heimer method, degenerating axons are present in the region of the deficit in immunoreactivity.

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Additional Information:© 1987 by Society for Neuroscience. For the first six months after publication SfN’s license will be exclusive. Beginning six months after publication the Work will be made freely available to the public on SfN’s website to copy, distribute, or display under a Creative Commons Attribution 4.0 International (CC BY 4.0) license ( Received Aug. 26, 1986; revised Dec. 30, 1986; accepted Jan. 27, 1987. We thank Dr. D.E.M. Lawson for giving us the primary antiserum; Ms. Marianne Cilluffo, Ms. Valerie Leathers, and Dr. A. W. Norman for their assistance in the isolation of calcium binding protein; Dr. Ngozi Erondu for his help in biochemical analysis; and Drs. David C. Van Essen and Leonard Maler for helpful discussions. This study was supported by National Science Foundation Grant BNS8411458 and NIH Grant NSl4617 to M. K. and by an A.F.P. Sloan Fellowship and NIH Grant NEI04067 to N.B.
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Alfred P. Sloan FoundationUNSPECIFIED
Issue or Number:6
PubMed Central ID:PMC6568887
Record Number:CaltechAUTHORS:20151202-112609132
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Official Citation:Calcium binding protein-like immunoreactivity labels the terminal field of nucleus laminaris of the barn owl TT Takahashi, CE Carr, N Brecha, and M Konishi The Journal of Neuroscience, 1 June 1987, 7(6):1843-1856
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:62544
Deposited By: Ruth Sustaita
Deposited On:02 Dec 2015 21:06
Last Modified:10 Nov 2021 23:03

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