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Temperature Dependence of Anesthesia in Goldfish

Cherkin, Arthur and Catchpool, J. F. (1964) Temperature Dependence of Anesthesia in Goldfish. Science, 144 (3625). pp. 1460-1462. ISSN 0036-8075. doi:10.1126/science.144.3625.1460.

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The anesthetizing concentrations in water of diethyl ether, chloroform, halothane (CF_3CClBrH), and methaxyflurane (CHCl_2CF_2OCH_3) have been determined for temperature-acclimated goldfish (Carassius auratus) at 5° to 30°C. At 20°C, the concentrations that anesthetize 50 percent of the fish are 2160, 167, 76.4, and 57.0 mg/ liter, respectively; the corresponding partial pressures are 13.0, 3.36, 4.12, and 0.67 mm-Hg. The anesthetizing partial pressures increase with body temperature, with enthalpies of 8.6, 13.2, 12.5, and 12.3 kcal/ mole, respectively.

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Additional Information:© 1964 American Association for the Advancement of Science. Received May 1, 1964. We thank Linus Pauling for his interest and generous advice, T. R. Sato for many suggestions, and P. Dacre, D. Davies, C. Leonard and V. Walker for technical assistance. The work reported in this article (contribution No. 3058) was supported by grants to the California Institute of Technology made by the Ford Foundation and the National Institutes of Health.
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Ford FoundationUNSPECIFIED
Issue or Number:3625
Record Number:CaltechAUTHORS:20151208-101655710
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Official Citation:Temperature Dependence of Anesthesia in Goldfish Arthur Cherkin and J. F. Catchpool Science 19 June 1964: 144 (3625), 1460-1462. [DOI:10.1126/science.144.3625.1460]
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:62692
Deposited By: Tony Diaz
Deposited On:08 Dec 2015 22:43
Last Modified:10 Nov 2021 23:05

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